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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Erbb3
erb-b2 receptor tyrosine kinase 3
MGI:95411
86 phenotypes from 10 alleles in 13 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Erbb3m3329Ddg/Erbb3m3329Ddg
involves: C3H/He * C57BL/6
abnormal axon fasciculation J:159834
abnormal dorsal root ganglion morphology J:159834
abnormal nervous system morphology J:159834
Erbb3m3329Ddg/Erbb3m3329Ddg
involves: C57BL/6
abnormal axon fasciculation J:160880
abnormal dorsal root ganglion morphology J:160880
abnormal mandibular nerve morphology J:160880
abnormal ophthalmic nerve morphology J:160880
abnormal spinal nerve morphology J:160880
embryonic lethality during organogenesis, incomplete penetrance J:160880
prenatal lethality, complete penetrance J:160880
Erbb3m3329Ddg/Erbb3tm1Gne
involves: 129S2/SvPas * C57BL/6
abnormal axon fasciculation J:160880
abnormal spinal nerve morphology J:160880
abnormal trigeminal nerve morphology J:160880
Erbb3tm1.1(ERBB3)Mul/Erbb3tm1.1(ERBB3)Mul
FVB.129P2(Cg)-Erbb3tm1.1(ERBB3)Mul
abnormal involution of the mammary gland J:189292
abnormal mammary gland alveolus morphology J:189292
abnormal mammary gland duct morphology J:189292
abnormal mammary gland epithelium morphology J:189292
abnormal mammary gland growth during lactation J:189292
decreased birth weight J:189292
decreased body weight J:189292
hypolactation J:189292
increased mammary gland apoptosis J:189292
postnatal growth retardation J:189292
preweaning lethality, incomplete penetrance J:189292
Erbb3tm1.1Dwt/Erbb3tm1.1Dwt
either: 129S6/SvEvTac-Erbb3tm1.1Dwt or B6.129S6-Erbb3tm1.1Dwt
lethality throughout fetal growth and development, incomplete penetrance J:152703
postnatal lethality, complete penetrance J:152703
Erbb3tm1.1Dwt/Erbb3tm2.1Dwt
involves: 129S6/SvEvTac * C57BL/6
no abnormal phenotype detected J:152703
Erbb3tm1.1Dwt/Erbb3tm2.1Dwt
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * CBA
preweaning lethality, complete penetrance J:152703
Erbb3tm1.1Dwt/Erbb3tm2.1Dwt
Tg(Vil1-cre)997Gum/0
involves: 129S6/SvEvTac * C57BL/6 * SJL
increased susceptibility to induced colitis J:152703
Erbb3tm1.1Squ/Erbb3tm1.1Squ
involves: 129S6/SvEvTac
no abnormal phenotype detected J:114524
Erbb3tm1Cbm/Erbb3tm1Cbm
either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)
abnormal cranial ganglia morphology J:43515
abnormal cranial nerve morphology J:43515
abnormal dorsal root ganglion morphology J:43515
abnormal PNS glial cell morphology J:43515
absent Schwann cell precursors J:43515
cyanosis J:43515
decreased body weight J:43515
embryonic lethality during organogenesis, incomplete penetrance J:43515
increased neuron apoptosis J:43515
motor neuron degeneration J:43515
neuron degeneration J:43515
no spontaneous movement J:43515
perinatal lethality, complete penetrance J:43515
respiratory failure J:43515
small dorsal root ganglion J:43515
unresponsive to tactile stimuli J:43515
Erbb3tm1Gne/Erbb3tm1Gne
involves: 129S2/SvPas * C57BL/6
abnormal atrioventricular valve development J:45302
abnormal brain morphology J:45302
abnormal brain ventricular system morphology J:45302
abnormal cardiac epithelial to mesenchymal transition J:45302
abnormal cerebellar plate morphology J:45302
abnormal cerebral aqueduct morphology J:45302
abnormal choroid plexus morphology J:45302
abnormal cranial flexure morphology J:45302
abnormal cranial ganglia morphology J:45302
abnormal embryonic neuroepithelial layer differentiation J:45302
abnormal enteric ganglia morphology J:45302
abnormal forebrain morphology J:45302
abnormal glial cell morphology J:45302
abnormal heart development J:45302
abnormal heart morphology J:45302
abnormal hindbrain morphology J:45302
abnormal midbrain morphology J:45302
abnormal myocardial trabeculae morphology J:45302
abnormal myocardium layer morphology J:45302
abnormal neocortex morphology J:45302
abnormal neuronal migration J:45302
abnormal pancreas morphology J:45302
abnormal pontine flexure morphology J:45302
abnormal stomach epithelium morphology J:45302
abnormal trigeminal ganglion morphology J:45302
abnormal ventral spinal root morphology J:45302
absent adrenergic chromaffin cells J:45302
absent cerebellum vermis J:45302
atrioventricular valve regurgitation J:45302
cerebellum hypoplasia J:45302
decreased Purkinje cell number J:45302
decreased Schwann cell number J:45302
embryonic lethality during organogenesis, complete penetrance J:45302
poor circulation J:45302
small nodose ganglion J:45302
small petrosal ganglion J:45302
thin atrioventricular cushion J:45302
Erbb3tm1Squ/Erbb3tm1Squ
Tg(EIIa-cre)C5379Lmgd/0
involves: 129S6/SvEvTac * FVB/N
abnormal atrioventricular valve morphology J:114524
abnormal dorsal root ganglion morphology J:114524
absent Schwann cells J:114524
embryonic lethality during organogenesis, incomplete penetrance J:114524
Erbb3tm1Squ/Erbb3tm1Squ
Tg(MMTV-cre)7Mul/0
involves: 129S6/SvEvTac * FVB/N
abnormal branching of the mammary ductal tree J:114524
Erbb3tm2Cbm/Erbb3tm2Cbm
either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)
abnormal cranial ganglia morphology J:43515
abnormal cranial nerve morphology J:43515
abnormal dorsal root ganglion morphology J:43515
abnormal PNS glial cell morphology J:43515
absent Schwann cell precursors J:43515
cyanosis J:43515
decreased body weight J:43515
embryonic lethality during organogenesis, incomplete penetrance J:43515
increased neuron apoptosis J:43515
motor neuron degeneration J:43515
neuron degeneration J:43515
no spontaneous movement J:43515
perinatal lethality, complete penetrance J:43515
respiratory failure J:43515
small dorsal root ganglion J:43515
unresponsive to tactile stimuli J:43515
Erbb3tm2Cbm/Erbb3tm2Cbm
involves: 129P2/OlaHsd
abnormal adrenal gland morphology J:48515
abnormal neural crest cell migration J:48515
abnormal paravertebral ganglion morphology J:48515
abnormal prevertebral ganglion morphology J:48515
abnormal superior cervical ganglion morphology J:48515
abnormal sympathetic ganglion morphology J:48515
abnormal sympathetic system morphology J:48515
absent adrenergic chromaffin cells J:48515
decreased noradrenaline level J:48515
small superior cervical ganglion J:48515
Erbb3tm3Cbm/Erbb3tm3Cbm
Tg(Dhh-cre)1Mejr/0
involves: 129P2/OlaHsd * FVB/N
absent Schwann cells J:207470

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/09/2024
MGI 6.23
The Jackson Laboratory