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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		En2
engrailed 2
MGI:95390
45 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
En1tm1Alj/En1+
En2tm1Alj/En2tm1Alj
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ 		normal nervous system phenotype J:84363
En1tm1Alj/En1tm1Alj
En2tm1Alj/En2+
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ 		absent cerebellum J:84363
En1tm1Alj/En1tm8.1Alj
En2tm1Alj/En2tm6Alj
Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster 		abnormal cerebellar foliation J:156169
abnormal cerebellar granule cell precursor proliferation J:156169
abnormal cerebellum development J:156169
abnormal cerebellum external granule cell layer morphology J:156169
abnormal cerebellum fissure morphology J:156169
abnormal cerebellum morphology J:156169
abnormal cerebellum posterior vermis morphology J:156169
abnormal cerebellum vermis lobule morphology J:156169
abnormal cerebellum vermis morphology J:156169
abnormal midbrain morphology J:156169
cerebellum vermis hypoplasia J:156169
decreased anterior vermis size J:156169
perinatal lethality, complete penetrance J:156169
small cerebellum J:156169
thin external granule cell layer J:156169
En1tm1Alj/En1tm8.1Alj
En2tm1Alj/En2tm7.1Alj
involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster 		abnormal cerebellar foliation J:156169
abnormal cerebellum hemisphere lobule morphology J:156169
abnormal cerebellum vermis lobule morphology J:156169
En1tm1Alj/En1tm8.1Alj
En2tm1Alj/En2tm7.1Alj
Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster 		abnormal cerebellar foliation J:156169
abnormal cerebellum hemisphere lobule morphology J:156169
abnormal cerebellum vermis lobule morphology J:156169
En1tm1Alj/En1tm8.1Alj
En2tm6Alj/En2+
Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster 		abnormal cerebellar foliation J:156169
abnormal cerebellum vermis lobule morphology J:156169
decreased anterior vermis size J:156169
En1tm1Gld/En1+
En2tm1Alj/En2tm1Alj
involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * Swiss Webster 		abnormal behavior J:115270
decreased dopamine level J:115270
decreased food intake J:115270
decreased grip strength J:115270
decreased locomotor activity J:115270
decreased neurotransmitter release J:115270
loss of dopaminergic neurons J:115270
slow postnatal weight gain J:115270
En1tm1Gld/En1tm1Gld
En2tm1Alj/En2+
involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * Swiss Webster 		decreased dopaminergic neuron number J:115270
perinatal lethality, complete penetrance J:115270
En1tm1Gld/En1tm1Gld
En2tm1Alj/En2tm1Alj
involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * Swiss Webster 		decreased dopaminergic neuron number J:115270
perinatal lethality, complete penetrance J:115270
En1tm2(cre)Wrst/En1tm8.1Alj
En2tm2Alj/En2+
involves: 129/Sv * Black Swiss * C57BL/6 * SJL * Swiss Webster 		absent cerebellum J:134516
absent inferior colliculus J:134516
decreased superior colliculus size J:134516
En1tm2(cre)Wrst/En1tm8.1Alj
En2tm2Alj/En2tm2Alj
involves: 129/Sv * Black Swiss * C57BL/6 * SJL * Swiss Webster 		absent cerebellum J:134516
absent colliculi J:134516
absent inferior colliculus J:134516
absent superior colliculus J:134516
absent tectum J:134516
En1tm2Alj/En1+
En2tm2Alj/En2+
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster 		abnormal cerebellar foliation J:134516
abnormal cerebellum anterior vermis morphology J:134516
abnormal cerebellum posterior vermis morphology J:134516
abnormal cerebellum vermis morphology J:134516
small cerebellum J:134516
En1tm2Alj/En1+
En2tm2Alj/En2tm2Alj
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster 		abnormal cerebellar foliation J:134516
abnormal cerebellum anterior vermis morphology J:134516
abnormal cerebellum morphology J:134516
abnormal cerebellum posterior vermis morphology J:134516
abnormal tectum morphology J:134516
absent cerebellum J:134516
absent cerebellum vermis J:134516
absent inferior colliculus J:134516
decreased inferior colliculus size J:134516
normal mortality/aging J:134516
small cerebellum J:134516
small tectum J:134516
En1tm2Alj/En1tm2Alj
En2tm2Alj/En2+
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster 		absent cerebellum J:134516
absent colliculi J:134516
absent inferior colliculus J:134516
absent superior colliculus J:134516
absent tectum J:134516
perinatal lethality, complete penetrance J:134516
En1tm2Alj/En1tm2Alj
En2tm2Alj/En2tm2Alj
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster 		abnormal midbrain-hindbrain boundary development J:66592
absent colliculi J:134516
absent inferior colliculus J:134516
absent midbrain J:66592
absent midbrain-hindbrain boundary J:66592
absent rhombomere 1 J:66592
absent superior colliculus J:134516
absent tectum J:134516
decreased rhombomere 1 size J:66592
small cerebellum J:134516
En1tm2Alj/En1tm3(En2)Alj
En2tm2Alj/En2tm2Alj
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster 		abnormal cerebellar foliation J:134516
abnormal cerebellum morphology J:134516
abnormal cerebellum posterior vermis morphology J:134516
decreased inferior colliculus size J:134516
small cerebellum J:134516
En1tm3(En2)Alj/En1tm3(En2)Alj
En2tm2Alj/En2+
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster 		normal nervous system phenotype J:134516
En1tm3(En2)Alj/En1tm3(En2)Alj
En2tm2Alj/En2tm2Alj
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster 		abnormal cerebellar foliation J:134516
abnormal cerebellum morphology J:134516
normal mortality/aging J:134516
small cerebellum J:134516
En1tm5(en)Alj/En1+
En2tm2Alj/En2tm2Alj
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster 		abnormal cerebellar foliation J:134516
abnormal cerebellum morphology J:134516
abnormal cerebellum posterior vermis morphology J:134516
decreased inferior colliculus size J:134516
small cerebellum J:134516
En1tm5(en)Alj/En1tm5(en)Alj
En2tm2Alj/En2+
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster 		abnormal cerebellum anterior vermis morphology J:134516
abnormal cerebellum posterior vermis morphology J:134516
decreased inferior colliculus size J:134516
decreased survivor rate J:134516
small cerebellum J:134516
En1tm5(en)Alj/En1tm5(en)Alj
En2tm2Alj/En2tm2Alj
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster 		absent cerebellum J:134516
absent inferior colliculus J:134516
absent superior colliculus J:134516
decreased superior colliculus size J:134516
perinatal lethality, complete penetrance J:134516
En1tm7(cre/ESR1)Alj/En1+
En2tm2Alj/En2tm2Alj
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
involves: 129S1/Sv * 129S4/SvJaeSor * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster 		abnormal cerebellum morphology J:134516
abnormal cerebellum vermis morphology J:134516
abnormal tectum morphology J:134516
decreased midbrain size J:134516
decreased rhombomere 1 size J:134516
En1tm8.1Alj/En1+
En2tm6Alj/En2+
Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
involves: 129S6/SvEvTac * Swiss Webster 		abnormal cerebellar foliation J:156169
abnormal cerebellum fissure morphology J:156169
abnormal cerebellum posterior vermis morphology J:156169
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory