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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Emx2
empty spiracles homeobox 2
MGI:95388
63 phenotypes from 4 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Emx2Pdo/Emx2+
involves: BALB/c
abnormal cochlea morphology J:250208
abnormal cochlear inner hair cell morphology J:250208
abnormal incus morphology J:250208
abnormal malleus morphology J:250208
abnormal middle ear ossicle morphology J:250208
abnormal stapes morphology J:250208
impaired hearing J:250208
increased cochlear nerve compound action potential J:250208
increased cochlear outer hair cell number J:250208
Emx2Pdo/Emx2+
involves: BALB/c * C3H/HeN
abnormal incudomalleolar joint morphology J:89093
abnormal incudostapedial joint morphology J:89093
abnormal incus long process morphology J:89093
abnormal malleus morphology J:89093
abnormal middle ear ossicle morphology J:82809, J:89093
abnormal stapes head morphology J:89093
absent incus lenticular process J:89093
absent pinna reflex J:89093
normal cardiovascular system phenotype J:89093
conductive hearing loss J:82809
deafness J:89093
decreased cochlear nerve compound action potential J:89093
increased cochlear inner hair cell number J:82809, J:89093
increased cochlear outer hair cell number J:82809, J:89093
sensorineural hearing loss J:82809
syndromic hearing loss J:82809
Emx2Pdo/Emx2Pdo
involves: BALB/c * C3H/HeN
abnormal malleus morphology J:89093
abnormal stapes head morphology J:89093
absent incus J:89093
neonatal lethality, complete penetrance J:89093
small kidney J:89093
Emx2Pdo/Emx2tm1Pgr
involves: 129S1/Sv * 129X1/SvJ * BALB/c * C3H/HeN * C57BL/6
absent incus J:89093
neonatal lethality, complete penetrance J:89093
small kidney J:89093
Emx2tm1Pgr/Emx2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal incudomalleolar joint morphology J:37631
abnormal malleus morphology J:89093
abnormal stapes morphology J:37631
absent incus J:37631, J:89093
increased cochlear inner hair cell number J:89093
increased cochlear outer hair cell number J:89093
Emx2tm1Pgr/Emx2tm1Pgr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal Ammon gyrus morphology J:37631
abnormal cerebral cortex morphology J:37631
abnormal cerebral hemisphere morphology J:37631
abnormal hippocampal fimbria morphology J:37631
abnormal lateral ventricle morphology J:37631
absent dentate gyrus J:37631
absent kidney J:37631
decreased anterior commissure size J:37631
decreased corpus callosum size J:37631
decreased hippocampal fornix size J:37631
dilated third ventricle J:37631
neonatal lethality, complete penetrance J:37631
small olfactory bulb J:37631
Emx2tm1Sia/Emx2tm1Sia
involves: C57BL/6 * CBA
abnormal kidney development J:40605
abnormal metanephric mesenchyme morphology J:40605
abnormal metanephric ureteric bud development J:40605
abnormal pallium development J:163926
abnormal primary sex determination J:40605
abnormal ureteric bud tip morphology J:40605
absent cranial vagina J:40605
absent dentate gyrus J:163926
absent efferent ductules of testis J:40605
absent epididymis J:40605
absent internal female genitalia J:40605
absent internal male genitalia J:40605
absent kidney J:40605
absent Mullerian ducts J:40605
absent ovary J:40605
absent oviduct J:40605
absent seminal vesicle J:40605
absent testes J:40605
absent ureter J:40605
absent uterus J:40605
absent vas deferens J:40605
agonadal J:40605
gonadal ridge hypoplasia J:40605
impaired branching involved in ureteric bud morphogenesis J:40605
increased metanephric mesenchyme apoptosis J:40605
neonatal lethality, complete penetrance J:40605
Wolffian duct degeneration J:40605
Emx2wndr/Emx2wndr
Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw
involves: BALB/c * C57BL/6 * C57BL/6J * FVB/N
abnormal axon extension J:168258
abnormal cerebral cortex morphology J:168258
neonatal lethality, complete penetrance J:168258
renal hypoplasia J:168258
small olfactory bulb J:168258

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/09/2024
MGI 6.23
The Jackson Laboratory