Edn3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Edn3
endothelin 3
MGI:95285

18 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Edn3^ls/Edn3⁺ involves: C57BL	abnormal melanosome morphology	J:12724
Edn3^ls/Edn3^ls involves: C57BL	abnormal enteric ganglia morphology	J:5008
	abnormal melanoblast morphology	J:12724
	abnormal melanosome morphology	J:12724
	megacolon	J:5008, J:12724
	postnatal lethality, complete penetrance	J:5008, J:12724
	variable body spotting	J:5008, J:12724
Edn3^tm1Ywa/Edn3^tm1Ywa involves: 129S7/SvEvBrd	abnormal colon morphology	J:22207
	absent enteric neurons	J:22207
	aganglionic megacolon	J:22207
	postnatal lethality, incomplete penetrance	J:22207
	premature death	J:22207
	variable body spotting	J:22207
Edn3^tmgc48/Edn3⁺ C57BL/6-19^PWK	variable body spotting	J:137432
Edn3^tmgc48/Edn3^tmgc48 C57BL/6-19^PWK	abnormal social/conspecific interaction behavior	J:92490
	postnatal lethality, incomplete penetrance	J:137432
	variable body spotting	J:137432
Tg(KRT14-Edn3)1Takk/? B6.Cg-Tg(KRT14-Edn3)1Takk	abnormal melanocyte morphology	J:104881
Tg(KRT14-Edn3)1Takk/? B6.Cg-Tg(KRT14-Edn3)1Takk	increased thyroid tumor incidence	J:104881
Tg(KRT14-Edn3)1Takk/? involves: C57BL/6 * DBA/2	abnormal skin pigmentation	J:100658
	darkened coat color	J:100658
	increased ear pigmentation	J:100658
	increased melanocyte number	J:100658

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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