Dbh Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dbh
dopamine beta hydroxylase
MGI:94864

22 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dbh^{tm1(flpo)Pjen}/Dbh⁺ involves: 129S7/SvEvBrd * C57BL/6J	no abnormal phenotype detected	J:198264
Dbh^{tm1(flpo)Pjen}/Dbh^{tm1(flpo)Pjen} involves: 129S7/SvEvBrd * C57BL/6J	embryonic lethality during organogenesis	J:198264
	prenatal lethality, complete penetrance	J:198264
Dbh^tm1Rpa/Dbh^tm1Rpa either: (involves: 129S7/SvEvBrd * 129/SvCpj) or (involves: 129S7/SvEvBrd * C57BL/6J)	abnormal heart morphology	J:24414
	absent circulating adrenaline	J:24414
	absent circulating noradrenaline	J:24414
	blepharoptosis	J:24414
	decreased body size	J:24414
	embryonic lethality during organogenesis, incomplete penetrance	J:24414
	increased circulating corticosterone level	J:97566
	increased dopamine level	J:24414
	neonatal lethality, incomplete penetrance	J:24414
	postnatal growth retardation	J:24414
	premature death	J:24414
Dbh^tm1Rpa/Dbh^tm1Rpa involves: 129S7/SvEvBrd * 129/SvCPJ * C57BL/6J	abnormal food intake	J:85772
	abnormal glucose homeostasis	J:85772
	decreased circulating glucagon level	J:85772
	decreased circulating glucose level	J:85772
	decreased glucagon secretion	J:85772
	increased circulating corticosterone level	J:85772
	increased circulating insulin level	J:85772
	insulin resistance	J:85772
Dbh^tm2(Th)Rpa/Dbh^tm2(Th)Rpa Not Specified	embryonic lethality during organogenesis, incomplete penetrance	J:30404
	postnatal growth retardation	J:30404
	postnatal lethality	J:30404

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23