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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Bach2
BTB and CNC homology, basic leucine zipper transcription factor 2
MGI:894679
46 phenotypes from 4 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Bach2m1Ccg/Bach2m1Ccg
C57BL/6-Bach2m1Ccg
decreased B cell number J:94077
decreased marginal zone B cell number J:94077
myeloid hyperplasia J:94077
Bach2m2Anu/Bach2m2Anu
C57BL/6NCrlAnu-Bach2m2Anu
decreased mature B cell number J:104190
increased IgM level J:104190
increased immature B cell number J:104190
Bach2tm1a(EUCOMM)Wtsi/Bach2tm1a(EUCOMM)Wtsi
C57BL/6N-Bach2tm1a(EUCOMM)Wtsi/Wtsi
abnormal bone structure J:211773
decreased B cell number J:211773
decreased bone mineral content J:211773
decreased bone mineral density J:211773
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number J:211773
decreased CD8-positive, naive alpha-beta T cell number J:211773
decreased circulating creatinine level J:211773
decreased circulating insulin level J:211773
decreased effector memory CD8-positive, alpha-beta T cell number J:211773
decreased gamma-delta T cell number J:211773
decreased mature B cell number J:211773
increased CD4-positive, alpha beta T cell number J:211773
increased effector memory CD4-positive, alpha-beta T cell number J:211773
increased effector memory CD8-positive, alpha-beta T cell number J:211773
increased effector memory T-helper cell number J:211773
increased eosinophil cell number J:211773
increased KLRG1+ CD4 alpha beta T cell number J:211773
increased KLRG1+ CD8 alpha beta T cell number J:211773
increased KLRG1-positive CD4-negative NK T cell number J:211773
increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number J:211773
increased KLRG1-positive gamma-delta T cell number J:211773
increased KLRG1-positive NK cell number J:211773
increased KLRG1-positive T-helper cell number J:211773
increased Ly6C low monocyte number J:211773
increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number J:211773
increased memory-marker CD4-negative NK T cell number J:211773
increased monocyte cell number J:211773
increased myeloid cell number J:211773
increased neutrophil cell number J:211773
increased NK cell number J:211773
Bach2tm1Igar/Bach2tm1Igar
involves: 129P2/OlaHsd * C57BL/6J
abnormal B cell differentiation J:91110
abnormal B cell physiology J:91110
abnormal class switch recombination J:91110
abnormal somatic hypermutation frequency J:91110
absent germinal center B cells J:91110
decreased B cell number J:91110
decreased IgA level J:91110
decreased IgG1 level J:91110
decreased IgG2a level J:91110
decreased IgG2b level J:91110
decreased IgG3 level J:91110
decreased IgG level J:91110
decreased mature B cell number J:91110
increased IgM level J:91110
spleen hypoplasia J:91110

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/03/2018
MGI 6.12
The Jackson Laboratory