Cyp1a2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
MGI:88589

19 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cyp1a2^tm1Dwn/Cyp1a2^tm1Dwn B6.129P2-Cyp1a2^tm1Dwn	abnormal liver physiology	J:88957
	abnormal physiological response to xenobiotic	J:147150
	abnormal xenobiotic pharmacokinetics	J:89337
	decreased incidence of tumors by chemical induction	J:97596
	decreased physiological sensitivity to xenobiotic	J:81115, J:97596
Cyp1a2^tm1Dwn/Cyp1a2^tm1Dwn either: (involves: 129P2/OlaHsd * Black Swiss) or (involves: 129P2/OlaHsd * CF-1)	enhanced behavioral response to xenobiotic	J:31730
Cyp1a2^tm1Gonz/Cyp1a2^tm1Gonz involves: 129S4/SvJae	abnormal lung development	J:25724
	abnormal pulmonary alveolar duct morphology	J:25724
	abnormal surfactant secretion	J:25724
	abnormal type II pneumocyte morphology	J:25724
	absent gastric milk in neonates	J:25724
	atelectasis	J:25724
	cyanosis	J:25724
	decreased body temperature	J:25724
	normal endocrine/exocrine gland phenotype	J:25724
	normal liver/biliary system phenotype	J:25724
	neonatal lethality, incomplete penetrance	J:25724
	postnatal lethality	J:25724
	respiratory distress	J:25724

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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