About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ctsb
cathepsin B
MGI:88561
24 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Cacna1atm2.1Kewa/Cacna1atm2.1Kewa
Ctsbtm1Jde/Ctsb+
involves: 129P2/OlaHsd * C57BL/6 		abnormal motor coordination/balance J:190729
Cacna1atm2.1Kewa/Cacna1atm2.1Kewa
Ctsbtm1Jde/Ctsbtm1Jde
involves: 129P2/OlaHsd * C57BL/6 		abnormal motor coordination/balance J:190729
abnormal Purkinje cell morphology J:190729
Purkinje cell degeneration J:190729
Cacna1atm3Hzo/Cacna1atm3Hzo
Ctsbtm1Jde/Ctsbtm1Jde
involves: 129P2/OlaHsd * 129S/SvEv 		Purkinje cell degeneration J:190729
Ctsbtm1Jde/Ctsbtm1Jde
Ctsktm1Psa/Ctsktm1Psa
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J 		abnormal thyroid follicle morphology J:83877
abnormal thyroid follicular cell morphology J:83877
abnormal thyroid hormone level J:83877
Ctsbtm1Jde/Ctsbtm1Jde
Ctsltm1Cptr/Ctsltm1Cptr
involves: 129P2/OlaHsd * C57BL/6J 		abnormal hippocampus pyramidal cell layer J:77103
abnormal motor coordination/balance J:77103
abnormal neuron apoptosis J:77103
decreased vertical activity J:77103
delayed hair appearance J:77103
gliosis J:77103
neuron degeneration J:77103
postnatal growth retardation J:77103
postnatal lethality, incomplete penetrance J:77103
Purkinje cell degeneration J:77103
thick epidermis J:77103
tremors J:77103
Ctsbtm1Jde/Ctsbtm1Jde
Ctsztm1Thre/Ctsztm1Thre
FVB.129P2-Ctsztm1Thre Ctsbtm1Jde 		no abnormal phenotype detected J:157541
Ctsbtm1Jde/Ctsbtm1Jde
Ctsztm1Thre/Ctsztm1Thre
Tg(MMTV-PyVT)634Mul/0
FVB.129P2-Ctsztm1Thre Ctsbtm1Jde Tg(MMTV-PyVT)634Mul 		abnormal tumor morphology J:157541
decreased apoptosis J:157541
decreased metastatic potential J:157541
decreased tumor growth/size J:157541
increased mammary gland tumor incidence J:157541
increased tumor latency J:157541
Ctsbtm1Jde/Ctsbtm1Jde
Serpina3gtm1.1Arp/Serpina3gtm1.1Arp
involves: 129P2/OlaHsd * C57BL/6 		normal immune system phenotype J:189782
Ctsbtm1Jde/Ctsbtm1Jde
Tg(MMTV-PyVT)634Mul/0
FVB.129P2-Ctsbtm1Jde Tg(MMTV-PyVT)634Mul 		abnormal tumor morphology J:157541
decreased metastatic potential J:157541
decreased tumor growth/size J:157541
increased mammary gland tumor incidence J:157541
increased tumor latency J:157541
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory