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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cr2
complement receptor 2
MGI:88489
37 phenotypes from 7 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cr2M1Btlr/Cr2M1Btlr
C57BL/6J-Cr2M1Btlr 		decreased IgG level J:267527
impaired humoral immune response J:267527
Cr2tm1.1Jhws/Cr2tm1.1Jhws
B6.Cg-Cr2tm1.1Jhws 		normal immune system phenotype J:155241
Cr2tm1.1Jhws/Cr2tm1.1Jhws
Not Specified 		abnormal germinal center B cell physiology J:205353
decreased B-1a cell number J:205353
decreased IgG2b level J:205353
decreased IgG2c level J:205353
decreased IgG3 level J:205353
decreased IgM level J:205353
normal immune system phenotype J:205353
increased susceptibility to bacterial infection induced morbidity/mortality J:205353
Cr2tm1Crr/Cr2tm1Crr
involves: 129S7/SvEvBrd 		decreased follicular B cell number J:69477
increased marginal zone B cell number J:69477
Cr2tm1Crr/Cr2tm1Crr
involves: 129S7/SvEvBrd * C57BL/6 		abnormal B-1 B cell morphology J:31942
abnormal humoral immune response J:31942, J:69452
abnormal immune system morphology J:69452
abnormal spleen germinal center morphology J:31942
decreased B cell number J:31942
decreased B-1a cell number J:69452
decreased IgG2a level J:31942
decreased IgG2b level J:31942
decreased IgG3 level J:31942
decreased IgG level J:31942, J:69452
decreased IgM level J:69452
decreased immunoglobulin level J:69452
decreased neutrophil cell number J:66111
decreased spleen germinal center number J:31942, J:69452
decreased spleen germinal center size J:31942
decreased tumor necrosis factor secretion J:66111
normal immune system phenotype J:31942
increased susceptibility to induced morbidity/mortality J:66111
increased susceptibility to injury J:66111
Cr2tm1Crr/Cr2tm1Crr
involves: 129S7/SvEvBrd * C57BL/6J 		increased anti-double stranded DNA antibody level J:111811
Cr2tm1Hmo/Cr2tm1Hmo
B6.129S7-Cr2tm1Hmo 		decreased susceptibility to injury J:78241
increased susceptibility to bacterial infection J:94855
normal renal/urinary system phenotype J:103238
Cr2tm1Hmo/Cr2tm1Hmo
involves: 129S7/SvEvBrd 		decreased IgG level J:35112
decreased IgM level J:35112
Cr2tm1Hmo/Cr2tm1Hmo
involves: 129S7/SvEvBrd * C57BL/6 		abnormal B cell activation J:151991
abnormal B cell physiology J:151991
abnormal class switch recombination J:151991
abnormal memory B cell differentiation J:151991
Cr2tm1Tft/Cr2tm1Tft
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal adaptive immunity J:95979
decreased IgG1 level J:95979
decreased IgG2b level J:95979
decreased IgG3 level J:95979
decreased IgG level J:95979
decreased IgM level J:95979
decreased spleen germinal center number J:95979
increased susceptibility to bacterial infection J:95979
Cr2tm2.1(HLA-A)Crr/Cr2tm2.1(HLA-A)Crr
involves: C57BL/6 		abnormal B cell physiology J:151991
abnormal class switch recombination J:151991
abnormal memory B cell differentiation J:151991
Cr2tm2.1Jhws/Cr2tm2.1Jhws
B6.129-Cr2tm2.1Jhws 		abnormal germinal center B cell physiology J:205353
decreased IgG3 level J:205353
decreased IgM level J:205353
normal immune system phenotype J:205353
increased IgM level J:205353
normal mortality/aging J:205353
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory