Chrm4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Chrm4
cholinergic receptor, muscarinic 4
MGI:88399

20 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Chrm4^{tm1b(EUCOMM)Hmgu}/Chrm4^{tm1b(EUCOMM)Hmgu} B6N(Cg)-Chrm4^{tm1b(EUCOMM)Hmgu}/J	hyperactivity	J:211773
	increased startle reflex	J:211773
Chrm4^tm1Jwe/Chrm4^tm1Jwe B6.129S6-Chrm4^tm1Jwe	abnormal vocalization	J:134260
Chrm4^tm1Jwe/Chrm4^tm1Jwe involves: 129S6/SvEvTac * CF-1	abnormal CNS synaptic transmission	J:112505
	abnormal gallbladder physiology	J:125455
	abnormal heart rate	J:60451
	decreased body weight	J:57480
	normal homeostasis/metabolism phenotype	J:57480
	impaired smooth muscle contractility	J:125455
	increased locomotor activity	J:57480
	normal muscle phenotype	J:60451
Chrm4^tm1Minm/Chrm4^tm1Minm involves: 129X1/SvJ * DBA/2J	abnormal behavioral response to xenobiotic	J:99248
Chrm4^tm1Minm/Chrm4^tm1Minm involves: 129X1/SvJ * DBA/2J	abnormal locomotor behavior	J:99248
Chrm4^tm2.1Jwe/Chrm4^tm2.1Jwe Tg(Drd1a-cre)AGsc/0 involves: 129S6/SvEvTac * C57BL/6 * FVB/N	abnormal neuron physiology	J:157841
	catalepsy	J:157841
	enhanced behavioral response to addictive substance	J:157841
	enhanced behavioral response to cocaine	J:157841
	enhanced behavioral response to xenobiotic	J:157841
	hyperactivity	J:157841
	impaired behavioral response to xenobiotic	J:157841
	increased dopamine level	J:157841

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23