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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Cdk1
cyclin-dependent kinase 1
MGI:88351
24 phenotypes from 7 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Cdk1Gt(P009F08)Bbd/Cdk1Gt(P009F08)Bbd
involves: 129/Sv * 129X1/SvJ * C57BL/6
embryonic lethality before implantation, complete penetrance J:124678
Cdk1Gt(P009F08)Bbd/Cdk1Gt(pGT1-3)1Bbd
involves: 129/Sv * 129P2/OlaHsd * 129X1/SvJ * C57BL/6
embryonic lethality during organogenesis, complete penetrance J:124678
Cdk1Gt(pGT1-3)1Bbd/Cdk1Gt(pGT1-3)1Bbd
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
embryonic lethality before implantation, complete penetrance J:124678
Cdk1tm1Eddy/Cdk1tm1Eddy
Tg(Cryaa-cre)10Mlr/0
involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N
abnormal lens development J:214812
abnormal lens epithelium morphology J:214812
abnormal lens fiber morphology J:214812
Cdk1tm2.1Kald/Cdk1tm2.1Kald
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129 * C57BL/6 * DBA * SJL
abnormal hepatocyte morphology J:182141
abnormal mitosis J:182141
abnormal response to injury J:182141
decreased hepatocyte number J:182141
decreased hepatocyte proliferation J:182141
decreased incidence of induced tumors J:182141
polyploidy J:182141
Cdk1tm2.1Kald/Cdk1tm2.1Kald
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129 * C57BL/6 * CBA * SJL
abnormal DNA replication J:182141
decreased cell proliferation J:182141
decreased tumor growth/size J:182141
early cellular replicative senescence J:182141
Cdk1tm2.2Kald/Cdk1tm2.2Kald
involves: 129 * C57BL/6 * FVB/N * SJL
abnormal blastocyst morphology J:182141
abnormal cell nucleus count J:182141
abnormal cell nucleus morphology J:182141
embryonic lethality, complete penetrance J:182141
failure of zygotic cell division J:182141
Cdk1tm3.1Kald/Cdk1+
involves: 129 * C57BL/6
embryonic lethality, complete penetrance J:251984
Cdk1tm3Kald/Cdk1+
Tg(Stra8-icre)1Reb/0
involves: 129 * C57BL/6 * FVB/NJ
arrest of male meiosis J:251984
azoospermia J:251984
small testis J:251984

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory