Cd40lg Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cd40lg
CD40 ligand
MGI:88337

15 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cd28^tm1Mak/Cd28^tm1Mak Cd40lg^tm1Flv/Cd40lg^tm1Flv NOD.Cg-Cd40lg^tm1Flv Cd28^tm1Mak	decreased regulatory T cell number	J:93421
	increased susceptibility to autoimmune diabetes	J:93421
	insulitis	J:93421
Cd40^tm1Kik/Cd40^tm1Kik Tg(Igh-V-CD40lg)#Tsub/0 involves: 129P2/OlaHsd * C57BL/6	no abnormal phenotype detected	J:89855
Cd40lg^tm1Flv/Cd40lg^tm1Flv Fas^lpr/Fas^lpr involves: 129P2/OlaHsd * 129S2/SvPas * MRL	abnormal kidney morphology	J:38492
	alopecia	J:38492
	decreased autoantibody level	J:38492
	decreased IgG level	J:38492
	decreased immunoglobulin level	J:38492
	extended life span	J:38492
	skin lesions	J:38492
Cd40lg^tm1Flv/Cd40lg^tm1Flv Fas^lpr/Fas^lpr Tcra^tm1Mjo/Tcra^tm1Mjo involves: 129P2/OlaHsd * 129S2/SvPas * MRL	abnormal kidney morphology	J:38492
	decreased autoantibody level	J:38492
	increased anti-double stranded DNA antibody level	J:38492
	normal integument phenotype	J:38492
Cd40lg^tm1Flv/Cd40lg^tm1Flv Tg(APPSWE)2576Kha/0 involves: 129S2/SvPas * C57BL/6 * SJL	amyloid beta deposits	J:80429
	gliosis	J:80429
Cd40lg^tm1Flv/Y Fas^lpr/Fas^lpr involves: 129P2/OlaHsd * 129S2/SvPas * MRL	abnormal kidney morphology	J:38492
	alopecia	J:38492
	decreased autoantibody level	J:38492
	decreased IgG level	J:38492
	decreased immunoglobulin level	J:38492
	extended life span	J:38492
	skin lesions	J:38492
Cd40lg^tm1Flv/Y Fas^lpr/Fas^lpr Tcra^tm1Mjo/Tcra^tm1Mjo involves: 129P2/OlaHsd * 129S2/SvPas * MRL	abnormal kidney morphology	J:38492
	decreased autoantibody level	J:38492
	increased anti-double stranded DNA antibody level	J:38492
	normal integument phenotype	J:38492

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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