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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Atp2a2
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
MGI:88110
74 phenotypes from 5 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Atp2a2tm1.1Iemr/Atp2a2+
Myl2tm1(cre)Krc/Myl2+
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6Crl * C57BL/6J
normal cardiovascular system phenotype J:155628
Atp2a2tm1.1Iemr/Atp2a2tm1.1Iemr
A1cfTg(Myh6-cre/Esr1*)1Jmk/0
involves: 129P2/OlaHsd * C57BL/6J * FVB/N
abnormal cardiovascular system physiology J:157143
abnormal heart left atrium morphology J:157143
abnormal heart left ventricle pressure J:157143
abnormal myocardial fiber physiology J:157143
normal cardiovascular system phenotype J:157143
decreased cardiac muscle contractility J:157143
decreased cardiac output J:157143
decreased heart rate J:157143
decreased systemic arterial systolic blood pressure J:157143
dilated heart atrium J:157143
enlarged heart J:157143
increased circulating noradrenaline level J:157143
Atp2a2tm1.1Iemr/Atp2a2tm1.1Iemr
Tg(Myhca-cre)1Lrsn/0
involves: 129P2/OlaHsd * C57BL/6Crl * FVB
embryonic lethality during organogenesis, complete penetrance J:155628
Atp2a2tm1.1Raco/Atp2a2+
C57BL/6J-Atp2a2tm1.1Raco/Raco
abnormal blood circulation J:216004
abnormal calcium ion homeostasis J:216004
abnormal physiological neovascularization J:216004
abnormal vascular endothelial cell migration J:216004
abnormal vascular endothelial cell physiology J:216004
decreased angiogenesis J:216004
Atp2a2tm1.1Raco/Atp2a2tm1.1Raco
C57BL/6J-Atp2a2tm1.1Raco/Raco
abnormal vascular development J:216004
decreased embryo size J:216004
embryonic lethality between somite formation and embryo turning, complete penetrance J:216004
Atp2a2tm1b(EUCOMM)Hmgu/Atp2a2+
C57BL/6N-Atp2a2tm1b(EUCOMM)Hmgu/H
abnormal sensory capabilities/reflexes/nociception J:211773
decreased circulating alkaline phosphatase level J:211773
decreased eosinophil cell number J:211773
decreased mean platelet volume J:211773
decreased prepulse inhibition J:211773
Atp2a2tm1b(EUCOMM)Hmgu/Atp2a2tm1b(EUCOMM)Hmgu
C57BL/6N-Atp2a2tm1b(EUCOMM)Hmgu/H
preweaning lethality, complete penetrance J:211773
Atp2a2tm1Fwuy/Atp2a2tm1Fwuy
involves: 129S1/Sv * 129X1/SvJ * Swiss
abnormal calcium ion homeostasis J:111247
abnormal cardiac muscle relaxation J:111247
abnormal heart shape J:111247
abnormal locomotor activation J:111247
aorta coarctation J:111247
ascending aorta hypoplasia J:111247
atrial septal defect J:111247
bradykinesia J:111247
cardiac fibrosis J:111247
cardiac hypertrophy J:111247
cardiac interstitial fibrosis J:111247
decreased body weight J:111247
decreased cardiac muscle contractility J:111247
decreased litter size J:111247
dilated heart right ventricle J:111247
fatigue J:111247
heart left ventricle hypertrophy J:111247
impaired righting response J:111247
increased heart weight J:111247
neonatal lethality, incomplete penetrance J:111247
prenatal lethality, incomplete penetrance J:111247
thick ventricular wall J:111247
thin ventricle myocardium compact layer J:111247
ventricular septal defect J:111247
Atp2a2tm1Ges/Atp2a2+
involves: 129X1/SvJ
abnormal osteoclast differentiation J:198051
Atp2a2tm1Ges/Atp2a2+
involves: 129X1/SvJ * Black Swiss
abnormal calcium ion homeostasis J:52186, J:66006
abnormal cardiac muscle relaxation J:52186, J:95608
cachexia J:69754
cardiac fibrosis J:69754, J:95608
cardiac hypertrophy J:95608
congestive heart failure J:95608
decreased left ventricle systolic pressure J:52186
decreased systemic arterial blood pressure J:52186
decreased ventricle muscle contractility J:52186, J:66006, J:95608
dilated heart left ventricle J:95608
esophageal epithelium hyperplasia J:69754
heart left ventricle hypertrophy J:95608
hyperkeratosis J:69754
increased esophageal papilloma incidence J:69754
increased left ventricle diastolic pressure J:95608
increased response of heart to induced stress J:95608
increased sensitivity to induced morbidity/mortality J:95608
increased skin papilloma incidence J:69754
increased squamous cell carcinoma incidence J:69754
increased tongue papilloma incidence J:69754
increased tumor incidence J:69754
lethargy J:69754
penis prolapse J:69754
premature death J:69754
pulmonary edema J:95608
stomach epithelial hyperplasia J:69754
thick ventricular wall J:95608
toenail hyperkeratosis J:69754
Atp2a2tm1Ges/Atp2a2tm1Ges
involves: 129X1/SvJ * Black Swiss
prenatal lethality, complete penetrance J:52186

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory