Atp1a2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Atp1a2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
MGI:88106

39 phenotypes from 7 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Atp1a2^tm1.1Gica/Atp1a2⁺ B6.Cg-Atp1a2^tm1.1Gica	abnormal nervous system electrophysiology	J:307518
	abnormal response to new environment	J:307518
	increased anxiety-related response	J:307518
	increased fear-related response	J:307518
Atp1a2^tm1.1Gica/Atp1a2^tm1.1Gica B6.Cg-Atp1a2^tm1.1Gica	neonatal lethality, complete penetrance	J:307518
Atp1a2^tm1.1Tmklh/Atp1a2⁺ B6.129S1(Cg)-Atp1a2^tm1.1Tmklh	abnormal emotion/affect behavior	J:259556
	abnormal impulsive behavior control	J:259556
	abnormal nervous system electrophysiology	J:259556
	abnormal social investigation	J:259556
	anhedonia	J:259556
	behavioral despair	J:259556
	decreased locomotor activity	J:259556
	excessive vocalization	J:259556
	impaired coordination	J:259556
	increased body weight	J:259556
	increased glutamic acid level	J:259556
	increased grooming behavior	J:259556
	increased startle reflex	J:259556
Atp1a2^tm1.1Tmklh/Atp1a2^tm1.1Tmklh involves: 129S1/Sv * C57BL/6J	abnormal hippocampus physiology	J:259556
	neonatal lethality, complete penetrance	J:259556
Atp1a2^tm1Kwk/Atp1a2⁺ involves: 129X1/SvJ * C57BL/6J	abnormal fear/anxiety-related behavior	J:83884
Atp1a2^tm1Kwk/Atp1a2^tm1Kwk involves: 129X1/SvJ * C57BL/6J	abnormal amygdala morphology	J:83884
	abnormal olfactory cortex morphology	J:83884
	normal embryo phenotype	J:83884
	neonatal lethality, complete penetrance	J:83884
Atp1a2^tm2Kwk/Atp1a2⁺ B6.129X1-Atp1a2^tm2Kwk	no abnormal phenotype detected	J:94810
Atp1a2^tm2Kwk/Atp1a2^tm2Kwk B6.129X1-Atp1a2^tm2Kwk	abnormal action potential	J:94810
	abnormal nervous system electrophysiology	J:94810
	abnormal somatic nervous system physiology	J:94810
	abnormal synaptic neurotransmitter level	J:94810
	increased gamma-aminobutyric acid level	J:94810
	neonatal lethality, complete penetrance	J:94810
	no spontaneous movement	J:94810
	respiratory failure	J:94810
	unresponsive to tactile stimuli	J:94810
Atp1a2^tm2Ling/Atp1a2⁺ involves: 129P2/OlaHsd	abnormal muscle contractility	J:114415
Atp1a2^tm2Ling/Atp1a2⁺ involves: 129P2/OlaHsd * Black Swiss	abnormal spatial learning	J:117414
	normal homeostasis/metabolism phenotype	J:117414
	increased anxiety-related response	J:117414
Atp1a2^tm2Ling/Atp1a2⁺ involves: 129P2/OlaHsd * C57BL/6 * Black Swiss	decreased cardiac muscle contractility	J:55191
Atp1a2^tm2Ling/Atp1a2^tm2Ling involves: 129P2/OlaHsd * C57BL/6 * Black Swiss	neonatal lethality, complete penetrance	J:55191
Atp1a2^tm3Ling/Atp1a2^tm3Ling involves: 129S6/SvEvTac * Black Swiss	abnormal cardiac muscle contractility	J:87082
	normal cardiovascular system phenotype	J:87082
Atp1a2^tm4.1Ling/Atp1a2^tm4.1Ling Tg(Tagln-cre)1Her/0 involves: Black Swiss * C57BL/6 * SJL	abnormal systemic arterial blood pressure	J:177051
	cardiac hypertrophy	J:177051
	normal cardiovascular system phenotype	J:177051
	increased heart weight	J:177051

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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