Serpinc1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Serpinc1
serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1
MGI:88095

33 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Serpinc1^{Gt(OST17473)Lex}/Serpinc1^{Gt(OST17473)Lex} involves: 129S5/SvEvBrd * C57BL/6J	preweaning lethality, complete penetrance	J:103485
Serpinc1^tm1Dwr/Serpinc1⁺ involves: 129S1/Sv * 129X1/SvJ	abnormal cardiac thrombosis	J:115658
	neonatal lethality, incomplete penetrance	J:115658
	venoocclusion	J:115658
Serpinc1^tm1Dwr/Serpinc1^tm1Dwr involves: 129S1/Sv * 129X1/SvJ	abnormal atrial thrombosis	J:115658
	abnormal blood coagulation	J:115658
	abnormal cardiac thrombosis	J:115658
	abnormal eye morphology	J:115658
	abnormal liver morphology	J:115658
	abnormal liver regeneration	J:115658
	abnormal optic choroid morphology	J:115658
	abnormal penis morphology	J:115658
	abnormal placental thrombosis	J:115658
	abnormal retina layer morphology	J:115658
	abnormal retina morphology	J:115658
	abnormal retina pigment epithelium morphology	J:115658
	abnormal sclera morphology	J:115658
	abnormal thrombosis	J:115658
	cornea perforation	J:115658
	decreased litter size	J:115658
	enlarged spleen	J:115658
	hepatic necrosis	J:115658
	liver inflammation	J:115658
	macrovesicular hepatic steatosis	J:115658
	neonatal lethality, incomplete penetrance	J:115658
	portal hypertension	J:115658
	postnatal lethality, incomplete penetrance	J:115658
	premature death	J:115658
	priapism	J:115658
	venoocclusion	J:115658
Serpinc1^tm1Sai/Serpinc1⁺ involves: 129S2/SvPas * C57BL/6J	increased susceptibility to induced thrombosis	J:75955
Serpinc1^tm1Sai/Serpinc1^tm1Sai involves: 129S2/SvPas * C57BL/6J	abnormal thrombosis	J:65092
	hemorrhage	J:65092
	intracranial hemorrhage	J:65092
	lethality throughout fetal growth and development, complete penetrance	J:65092
	liver degeneration	J:65092
	myocardial fiber degeneration	J:65092

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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