About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Ank2
ankyrin 2, brain
MGI:88025
63 phenotypes from 6 alleles in 8 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Ank2em1Bnt/Ank2+
C57BL/6J-Ank2em1Bnt
abnormal axon morphology J:277752
normal behavior/neurological phenotype J:277752
enhanced spatial learning J:277752
Ank2em1Bnt/Ank2em1Bnt
C57BL/6J-Ank2em1Bnt
abnormal axon morphology J:277752
abnormal brain morphology J:277752
abnormal excitatory synapse morphology J:277752
abnormal miniature excitatory postsynaptic currents J:277752
abnormal social/conspecific interaction behavior J:277752
normal behavior/neurological phenotype J:277752
decreased locomotor activity J:277752
decreased paired-pulse facilitation J:277752
decreased vocalization J:277752
enhanced spatial learning J:277752
increased grooming behavior J:277752
increased miniature excitatory postsynaptic current amplitude J:277752
increased miniature excitatory postsynaptic current frequency J:277752
normal taste/olfaction phenotype J:277752
Ank2em1Melr/Ank2em1Melr
B6.Cg-Ank2em1Melr
abnormal heart echocardiography feature J:338515
abnormal myocardial fiber physiology J:338515
cardiac fibrosis J:338515
decreased cardiac muscle contractility J:338515
decreased heart rate J:338515
increased response of heart to induced stress J:338515
irregular heartbeat J:338515
prolonged QT interval J:338515
prolonged RR interval J:338515
sinus bradycardia J:338515
Ank2tm1Bnt/Ank2+
involves: 129
abnormal fat cell differentiation J:222913
abnormal physiological response to xenobiotic J:163867
abnormal sinoatrial node conduction J:163867
decreased adipocyte glucose uptake J:222913
increased heart rate variability J:163867
Ank2tm1Bnt/Ank2tm1Bnt
B6.129-Ank2tm1Bnt/Bnt
abnormal social/conspecific interaction behavior J:277752
decreased vocalization J:277752
enhanced spatial learning J:277752
Ank2tm1Bnt/Ank2tm1Bnt
involves: 129
normal nervous system phenotype J:186168
Ank2tm1Bnt/Ank2tm1Bnt
involves: 129X1/SvJ * C57BL/6
abnormal anterior corticospinal tract morphology J:52124
abnormal axon morphology J:52124
abnormal lateral corticospinal tract morphology J:52124
abnormal locomotor behavior J:52124
decreased body weight J:52124
decreased brain internal capsule size J:52124
decreased corpus callosum size J:52124
disorganized secondary lens fibers J:52124, J:70385
enlarged lateral ventricles J:52124
impaired balance J:52124
neonatal lethality, incomplete penetrance J:52124
optic nerve degeneration J:52124
postnatal lethality, complete penetrance J:52124
Ank2tm2.1Bnt/Ank2+
STOCK Ank2tm2Bnt/J
impaired glucose tolerance J:222913
premature death J:222913
Ank2tm2.1Bnt/Ank2tm2.1Bnt
STOCK Ank2tm2Bnt/J
abnormal fat cell differentiation J:222913
abnormal gluconeogenesis J:222913
normal behavior/neurological phenotype J:222913
normal homeostasis/metabolism phenotype J:222913
impaired glucose tolerance J:222913
increased adipocyte glucose uptake J:222913
increased body weight J:222913
increased circulating free fatty acids level J:222913
increased circulating glucose level J:222913
increased epididymal fat pad weight J:222913
increased fat cell size J:222913
increased susceptibility to age related obesity J:222913
increased susceptibility to diet-induced hepatic steatosis J:222913
increased susceptibility to diet-induced obesity J:222913
insulin resistance J:222913
normal muscle phenotype J:222913
Ank2tm3.1Bnt/Ank2+
B6.129(C)-Ank2tm3.1Bnt/J
impaired glucose tolerance J:222913
increased circulating glucose level J:222913
increased susceptibility to age related obesity J:222913
premature death J:222913
Ank2tm3.1Bnt/Ank2tm3.1Bnt
B6.129(C)-Ank2tm3.1Bnt/J
abnormal fat cell differentiation J:222913
abnormal gluconeogenesis J:222913
abnormal glucose homeostasis J:222913
normal behavior/neurological phenotype J:222913
decreased adipocyte glucose uptake J:222913
decreased circulating insulin level J:222913
decreased insulin secretion J:222913
decreased muscle cell glucose uptake J:222913
normal homeostasis/metabolism phenotype J:222913
impaired glucose tolerance J:222913
increased adipocyte glucose uptake J:222913
increased body weight J:222913
increased circulating free fatty acids level J:222913
increased circulating glucose level J:222913
increased epididymal fat pad weight J:222913
increased fat cell size J:222913
increased muscle cell glucose uptake J:222913
increased susceptibility to age related obesity J:222913
increased susceptibility to diet-induced hepatic steatosis J:222913
increased susceptibility to diet-induced obesity J:222913
increased total body fat amount J:222913
insulin resistance J:222913
Ank2tm4.1Bnt/Ank2+
Tg(Nes-cre)1Kln/0
B6.Cg-Ank2tm4.1Bnt Tg(Nes-cre)1Kln
abnormal axon morphology J:277752
abnormal social/conspecific interaction behavior J:277752
decreased vocalization J:277752
enhanced spatial learning J:277752

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
04/16/2024
MGI 6.23
The Jackson Laboratory