52 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Akt1Gt1Pnt/Akt1Gt1Pnt Tg(MMTV-Erbb2)NK1Mul/Tg(MMTV-Erbb2)NK1Mul involves: 129 * C57BL/6 * FVB/N	increased mammary adenocarcinoma incidence	J:117336
Akt1Gt1Pnt/Akt1Gt1Pnt Tg(MMTV-PyVT)634Mul/0 involves: 129 * C57BL/6 * FVB/N	increased mammary adenocarcinoma incidence	J:117336
Akt1tm1Hem/Akt1+ Akt2tm1Hem/Akt2tm1Hem Akt3tm1Hem/Akt3tm1Hem involves: 129P2/OlaHsd * C57BL/6	decreased body size	J:114675
	decreased body weight	J:114675
Akt1tm1Hem/Akt1tm1Hem Akt2tm1Hem/Akt2tm1Hem Akt3tm1Hem/Akt3tm1Hem involves: 129P2/OlaHsd * C57BL/6	prenatal lethality, complete penetrance	J:114675
Akt1tm1Mbb/Akt1+ Flt1tm1Jrt/Flt1+ involves: 129P2/OlaHsd	normal cardiovascular system phenotype	J:151369
Akt1tm1Nhy/Akt1+ Akt2tm1Rsg/Akt2tm1Rsg involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1LacJ	decreased circulating leptin level	J:149156
	decreased insulin secretion	J:149156
	decreased pancreatic beta cell number	J:149156
	decreased percent body fat/body weight	J:149156
	decreased white adipose tissue amount	J:149156
	enlarged pancreatic islets	J:149156
	hyperglycemia	J:149156
	impaired glucose tolerance	J:149156
	increased circulating insulin level	J:149156
Akt1tm1Nhy/Akt1+ Akt2tm1Rsg/Akt2tm1Rsg Akt3tm1Nhy/Akt3tm1Nhy involves: 129/Sv * C57BL/6 * DBA/1LacJ	hyperglycemia	J:149156
Akt1tm1Nhy/Akt1+ Akt2tm1Rsg/Akt2tm1Rsg Ptentm1Ppp/Pten+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1LacJ	enlarged pancreatic islets	J:149156
	impaired glucose tolerance	J:149156
	increased circulating insulin level	J:149156
Akt1tm1Nhy/Akt1tm1Nhy Akt2tm1Rsg/Akt2tm1Rsg involves: 129/Sv * C57BL/6 * DBA/1LacJ	abnormal keratinocyte morphology	J:83741
	abnormal lipid homeostasis	J:83741
	decreased birth weight	J:83741
	decreased fetal weight	J:83741
	decreased hair follicle number	J:83741
	delayed bone ossification	J:83741
	muscle hypoplasia	J:83741
	perinatal lethality	J:83741
	respiratory distress	J:83741
	thin epidermis stratum spinosum	J:83741
	thin skin	J:83741
	translucent skin	J:83741
	underdeveloped hair follicles	J:83741
Akt1tm1Pnt/Akt1tm1Pnt Akt2tm1.1Mbb/Akt2tm1.1Mbb Akt3tm1Mbb/Akt3tm1Mbb Tg(Lck-cre)1Cwi/0 involves: 129P2/OlaHsd	arrested T cell differentiation	J:135903
	decreased double-positive T cell number	J:135903
	increased double-negative T cell number	J:135903
	increased T cell apoptosis	J:135903
	thymus hypoplasia	J:135903
Akt1tm1Pnt/Akt1tm1Pnt Akt2tm1.1Mbb/Akt2tm1.1Mbb Tg(Lck-cre)1Cwi/0 involves: 129P2/OlaHsd	arrested T cell differentiation	J:135903
	decreased double-positive T cell number	J:135903
	increased double-negative T cell number	J:135903
	increased T cell apoptosis	J:135903
	thymus hypoplasia	J:135903
Akt1tm1Pnt/Akt1tm1Pnt Akt3tm1Mbb/Akt3tm1Mbb Tg(Lck-cre)1Cwi/0 Not Specified	decreased double-positive T cell number	J:135903
	thymus hypoplasia	J:135903
Akt1tm1Zzy/Akt1tm1Zzy Akt3tm1Hem/Akt3tm1Hem Tg(Myh6-cre)1Xya/0 involves: 129P2/OlaHsd * FVB	abnormal physiological response to xenobiotic	J:206783
	decreased heart weight	J:206783
Gt(ROSA)26Sortm1(Akt1/EGFP)Glas/Gt(ROSA)26Sor+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	decreased total body fat amount	J:94134
	increased muscle weight	J:94134
	increased skeletal muscle fiber size	J:94134
	increased skeletal muscle size	J:94134
Rb1tm2Brn/Rb1tm2Brn Tg(KRT14-cre)8Brn/0 Tg(KRT5-Akt1*)Jmpa/0 involves: 129 * C57BL/6 * DBA/2 * DBA/2J * FVB/N	abnormal oral mucosa morphology	J:144831
	increased tumor incidence	J:144831
Tg(KRT5-Akt1*)Jmpa/0 involves: C57BL/6 * DBA/2 * DBA/2J * FVB/N	abnormal oral mucosa morphology	J:144831
	abnormal palatine gland morphology	J:144831
	abnormal sublingual gland morphology	J:144831
	abnormal tumor morphology	J:144831
	decreased keratinocyte proliferation	J:144831
	increased adenocarcinoma incidence	J:144831
	increased carcinoma incidence	J:144831
	increased cell proliferation	J:144831
	increased squamous cell carcinoma incidence	J:144831
	increased trichoepithelioma incidence	J:144831
	oral erythroplakia	J:144831
	oral leukoplakia	J:144831
Tg(KRT14-cre)8Brn/0 Tg(KRT5-Akt1*)Jmpa/0 Trp53tm1Brn/Trp53tm1Brn involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * DBA/2J * FVB/N	abnormal tumor morphology	J:144831
	increased carcinoma incidence	J:144831
	increased cell proliferation	J:144831
	increased keratinocyte proliferation	J:144831
	increased squamous cell carcinoma incidence	J:144831