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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Agtr1a
angiotensin II receptor, type 1a
MGI:87964
59 phenotypes from 11 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Agtr1atm1.1Cof/Agtr1atm1.1Cof
Hprttm1(Pck1-cre)Vhh/Hprt+
involves: 129 * 129P2/OlaHsd
abnormal renal water reabsorbtion J:172240
decreased renal glomerular filtration rate J:172240
decreased systemic arterial systolic blood pressure J:172240
Agtr1atm1.1Uky/Agtr1atm1.1Uky
Tg(Fabp4-cre)1Rev/0
involves: C57BL/6 * C57BL/6N * SJL
abnormal adipose tissue development J:192945
normal adipose tissue phenotype J:192945
decreased white fat cell number J:192945
normal growth/size/body region phenotype J:192945
normal homeostasis/metabolism phenotype J:192945
increased white fat cell size J:192945
Agtr1atm1Afu/Agtr1a+
involves: C57BL/6 * CBA * ICR
decreased systemic arterial systolic blood pressure J:28041
normal homeostasis/metabolism phenotype J:28041
hypotension J:28041
Agtr1atm1Afu/Agtr1atm1Afu
involves: C57BL/6 * CBA
abnormal kidney interstitium morphology J:69294
hypotension J:91164
Agtr1atm1Afu/Agtr1atm1Afu
involves: C57BL/6 * CBA * ICR
decreased systemic arterial systolic blood pressure J:28041, J:107851
hypotension J:28041
increased circulating renin level J:28041
increased fluid intake J:107851
increased renin activity J:28041
Agtr1atm1Ecl/Agtr1atm1Ecl
involves: 129S2/SvPas * C57BL/6
abnormal blood homeostasis J:124206
abnormal cardiovascular system physiology J:124206
abnormal heart left ventricle morphology J:124206
abnormal kidney blood vessel morphology J:124206
abnormal kidney physiology J:124206
cardiac fibrosis J:124206
cardiac interstitial fibrosis J:124206
decreased body weight J:124206
decreased circulating angiotensinogen level J:124206
decreased circulating renin level J:124206
decreased physiological sensitivity to xenobiotic J:124206
decreased urine creatinine level J:124206
decreased urine potassium level J:124206
high mean erythrocyte cell number J:124206
increased blood urea nitrogen level J:124206
increased heart weight J:124206
increased hemoglobin content J:124206
increased systemic arterial systolic blood pressure J:124206
increased urine osmolality J:124206
oliguria J:124206
renal fibrosis J:124206
Agtr1atm1Tma/Agtr1atm1Tma
involves: 129P2/OlaHsd * C57BL/6
abnormal juxtaglomerular apparatus morphology J:36090
abnormal kidney interlobular artery morphology J:36090
increased systemic arterial blood pressure J:46007
juxtaglomerular cell hyperplasia J:36090
Agtr1atm1Uky/Agtr1atm1Uky
Tg(Tagln-cre)1Her/0
involves: C57BL/6 * C57BL/6N * SJL
normal cardiovascular system phenotype J:170230
Agtr1atm1Unc/Agtr1a+
involves: 129P2/OlaHsd * C57BL/6J
abnormal systemic arterial blood pressure J:24354
decreased systemic arterial blood pressure J:24354
decreased systemic arterial systolic blood pressure J:24354
Agtr1atm1Unc/Agtr1atm1Unc
involves: 129P2/OlaHsd
abnormal amygdala morphology J:102774
abnormal thalamus morphology J:102774
Agtr1atm1Unc/Agtr1atm1Unc
involves: 129P2/OlaHsd * C57BL/6
abnormal heart rate J:137944
abnormal physiological response to xenobiotic J:137944
abnormal response/metabolism to endogenous compounds J:137944
abnormal systemic arterial blood pressure J:137944
decreased heart rate J:137944
decreased heart weight J:137944
decreased mean systemic arterial blood pressure J:137944
Agtr1atm1Unc/Agtr1atm1Unc
involves: 129P2/OlaHsd * C57BL/6J
abnormal systemic arterial blood pressure J:24354
decreased systemic arterial blood pressure J:24354
decreased systemic arterial systolic blood pressure J:24354
Agtr1atm2Tma/Agtr1atm2Tma
involves: 129P2/OlaHsd * C57BL/6
abnormal juxtaglomerular apparatus morphology J:36090
abnormal kidney interlobular artery morphology J:36090
juxtaglomerular cell hyperplasia J:36090
Agtr1atm3Tma/Agtr1atm3Tma
Tg(Nphs1-cre)10Mska/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2
normal cardiovascular system phenotype J:240316
normal homeostasis/metabolism phenotype J:240316
normal renal/urinary system phenotype J:240316
Hprttm1(Ggt1-Agtr1)Cof/Y
involves: 129P2/OlaHsd
no abnormal phenotype detected J:91837
Tg(Myh6-Agtr1a)4-7Vjd/0
FVB/N-Tg(Myh6-Agtr1a)4-7Vjd
abnormal impulse conducting system conduction J:40974
atrioventricular block J:40974
decreased heart rate J:40974
enlarged heart atrium J:40974
heart hyperplasia J:40974
increased heart weight J:40974
perinatal lethality, incomplete penetrance J:40974
prolonged PR interval J:40974
prolonged QRS complex duration J:40974

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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory