Aco1 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Aco1
aconitase 1
MGI:87879

16 phenotypes from 6 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Aco1^em1(IMPC)J/Aco1^em1(IMPC)J C57BL/6NJ-Aco1^em1(IMPC)J/Mmjax	abnormal retina morphology	J:211773
	decreased mean corpuscular volume	J:211773
Aco1^tm1.1Mwh/Aco1^tm1.1Mwh involves: 129P2/OlaHsd * C57BL/6 * SJL	no abnormal phenotype detected	J:103414
Aco1^tm1.2Mwh/Aco1^tm1.2Mwh involves: 129P2/OlaHsd * C57BL/6J	normal mortality/aging	J:103414
	no abnormal phenotype detected	J:104538
Aco1^tm1Mwh/Aco1^tm1Mwh involves: 129P2/OlaHsd * C57BL/6J	lethality throughout fetal growth and development, incomplete penetrance	J:103414, J:104538
Aco1^tm1Roua/Aco1^tm1Roua involves: C57BL/6	abnormal iron homeostasis	J:87889
Gt(ROSA)26Sor^{tm1.1(Aco1)Mwh}/Gt(ROSA)26Sor^{tm1.1(Aco1)Mwh} B6.129P2(129S1)-Gt(ROSA)26Sor^{tm1.1(Aco1*)Mwh}	abnormal erythropoiesis	J:196374
	decreased erythrocyte cell number	J:196374
	decreased hematocrit	J:196374
	decreased hemoglobin content	J:196374
	normal homeostasis/metabolism phenotype	J:196374
	increased intestinal iron level	J:196374
	increased liver iron level	J:196374
	increased mean corpuscular hemoglobin	J:196374
	increased mean corpuscular volume	J:196374
	increased spleen iron level	J:196374
	normal mortality/aging	J:196374

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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