Sh3gl2 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sh3gl2
SH3-domain GRB2-like 2
MGI:700009

19 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Sh3gl1^tm1Pdc/Sh3gl1^tm1Pdc Sh3gl2^tm1Pdc/Sh3gl2⁺ Sh3gl3^tm1.2Itl/Sh3gl3^tm1.2Itl involves: 129S1/Sv * C57BL/6 * C57BL/6J * FVB/N * SJL	seizures	J:178947
Sh3gl1^tm1Pdc/Sh3gl1^tm1Pdc Sh3gl2^tm1Pdc/Sh3gl2^tm1Pdc involves: 129	abnormal axon morphology	J:178947
	abnormal hippocampal mossy fiber morphology	J:178947
	decreased body weight	J:178947
	impaired coordination	J:178947
	neonatal lethality, incomplete penetrance	J:178947
	neurodegeneration	J:178947
	postnatal growth retardation	J:178947
	seizures	J:178947
Sh3gl1^tm1Pdc/Sh3gl1^tm1Pdc Sh3gl2^tm1Pdc/Sh3gl2^tm1Pdc Sh3gl3^tm1.2Itl/Sh3gl3^tm1.2Itl involves: 129S1/Sv * C57BL/6 * C57BL/6J * FVB/N * SJL	abnormal miniature excitatory postsynaptic currents	J:178947
	abnormal synapse morphology	J:178947
	abnormal synaptic vesicle number	J:178947
	abnormal synaptic vesicle recycling	J:178947
	absent gastric milk in neonates	J:178947
	decreased birth body size	J:178947
	decreased excitatory postsynaptic current amplitude	J:178947
	increased synaptic depression	J:178947
	neonatal lethality, complete penetrance	J:178947
	respiratory distress	J:178947
Sh3gl2^tm1Pdc/Sh3gl2^tm1Pdc Sh3gl3^tm1.2Itl/Sh3gl3^tm1.2Itl involves: 129S1/Sv * C57BL/6 * C57BL/6J * FVB/N * SJL	normal mortality/aging	J:178947

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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