Sle21 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sle21
systematic lupus erythematosus susceptibility 21
MGI:5620665

22 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
C1qa^tm1Mjw/C1qa^tm1Mjw Sle21^129P2/Ola/? Sle18^C57BL/6/Sle18^C57BL/6 involves: 129P2/Ola * 129S/SvEv * C57BL/6	increased anti-nuclear antigen antibody level	J:118645
	increased susceptibility to systemic lupus erythematosus	J:118645
C1qa^tm1Mjw/C1qa^tm1Mjw Sle21^129P2/Ola/Sle21^129P2/Ola involves: 129P2/Ola * 129S/SvEv * C57BL/6	increased anti-chromatin antibody level	J:118645
	increased anti-double stranded DNA antibody level	J:118645
	increased anti-nuclear antigen antibody level	J:118645
	increased anti-single stranded DNA antibody level	J:118645
	increased susceptibility to systemic lupus erythematosus	J:118645
C1qa^tm1Mjw/C1qa^tm1Mjw Sle21^129P2/Ola/Sle21^C57BL/6 involves: 129P2/Ola * 129S/SvEv * C57BL/6	increased anti-chromatin antibody level	J:118645
	increased anti-double stranded DNA antibody level	J:118645
	increased anti-nuclear antigen antibody level	J:118645
	increased anti-single stranded DNA antibody level	J:118645
	increased susceptibility to systemic lupus erythematosus	J:118645
Fcgr2b^tm1Ttk/Fcgr2b^tm1.2Jsv Sle21^129P2/Ola/Sle21^C57BL/6 involves: 129P2/Ola * 129S4/SvJae * C57BL/6 * FVB/N	abnormal kidney morphology	J:179175
	albuminuria	J:179175
	enlarged spleen	J:179175
	increased anti-chromatin antibody level	J:179175
	increased anti-double stranded DNA antibody level	J:179175
	increased anti-histone antibody level	J:179175
	increased anti-single stranded DNA antibody level	J:179175
	increased spleen weight	J:179175
	increased susceptibility to systemic lupus erythematosus	J:179175
	premature death	J:179175
Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk Sle21^129P2/Ola/Sle21^129P2/Ola B6.129S4-Fcgr2b^tm1Ttk	abnormal adaptive immunity	J:179175
	abnormal glomerular capillary thrombosis	J:179175
	abnormal renal glomerulus morphology	J:179175
	albuminuria	J:179175
	enlarged spleen	J:179175
	increased anti-chromatin antibody level	J:179175
	increased anti-double stranded DNA antibody level	J:179175
	increased anti-histone antibody level	J:179175
	increased anti-single stranded DNA antibody level	J:179175
	increased autoantibody level	J:179175
	increased IgG2a level	J:179175
	increased immunoglobulin level	J:179175
	increased spleen weight	J:179175
	increased susceptibility to induced arthritis	J:179175
	increased susceptibility to systemic lupus erythematosus	J:179175
	kidney inflammation	J:179175
	premature death	J:179175
Fcgr3^tm1Jsv/Fcgr3^tm1Jsv Sle21^129P2/Ola/Sle21^129P2/Ola B6.129P2-Fcgr3^tm1Jsv	enlarged spleen	J:179175
	increased activated T cell number	J:179175
	increased anti-chromatin antibody level	J:179175
	increased anti-double stranded DNA antibody level	J:179175
	increased anti-histone antibody level	J:179175
	increased anti-single stranded DNA antibody level	J:179175
	increased B cell number	J:179175
	increased spleen weight	J:179175
	normal mortality/aging	J:179175

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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