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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Piezo1
piezo-type mechanosensitive ion channel component 1
MGI:3603204
37 phenotypes from 5 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Piezo1Gt(RST343)Byg/Piezo1+
involves: 129P2/OlaHsd * C57BL/6J
normal no abnormal phenotype detected J:212179
Piezo1Gt(RST343)Byg/Piezo1Gt(RST343)Byg
involves: 129P2/OlaHsd * C57BL/6J
abnormal developmental vascular remodeling J:212179
abnormal intersomitic vessel morphology J:212179
abnormal vitelline vascular remodeling J:212179
absent organized vascular network J:212179
normal cardiovascular system phenotype J:212179
disorganized yolk sac vascular plexus J:212179
embryonic growth retardation J:212179
embryonic lethality during organogenesis, incomplete penetrance J:212179
lethality throughout fetal growth and development, complete penetrance J:212179
pericardial effusion J:212179
Piezo1tm1a(KOMP)Wtsi/Piezo1+
involves: C57BL/6J * C57BL/6N
abnormal vascular endothelial cell morphology J:217082
Piezo1tm1a(KOMP)Wtsi/Piezo1tm1a(KOMP)Wtsi
involves: C57BL/6J * C57BL/6N
abnormal enzyme/coenzyme activity J:217082
abnormal vascular endothelial cell morphology J:217082
abnormal vascular endothelial cell physiology J:217082
abnormal vitelline vasculature morphology J:217082
disorganized yolk sac vascular plexus J:217082
embryonic growth retardation J:217082
embryonic lethality during organogenesis, incomplete penetrance J:217082
lethality throughout fetal growth and development, complete penetrance J:217082
Piezo1tm1b(KOMP)Wtsi/Piezo1+
C57BL/6N-Piezo1tm1b(KOMP)Wtsi/MbpMmucd
abnormal embryo size J:211773
abnormal eye morphology J:211773
abnormal placenta size J:211773
pale yolk sac J:211773
pallor J:211773
Piezo1tm1b(KOMP)Wtsi/Piezo1+
C57BL/6N-Piezo1tm1b(KOMP)Wtsi/Ucd
abnormal urinary bladder morphology J:211773
increased mean corpuscular hemoglobin J:211773
Piezo1tm1b(KOMP)Wtsi/Piezo1tm1b(KOMP)Wtsi
C57BL/6N-Piezo1tm1b(KOMP)Wtsi/MbpMmucd
abnormal embryo size J:211773
abnormal limb bud morphology J:211773
abnormal placenta size J:211773
embryonic growth retardation J:211773
embryonic lethality prior to tooth bud stage J:211773
pale yolk sac J:211773
pallor J:211773
Piezo1tm1c(KOMP)Wtsi/Piezo1tm1c(KOMP)Wtsi
Tg(Tek-cre)12Flv/0
involves: C57BL/6J * C57BL/6N
abnormal vitelline vasculature morphology J:217082
embryonic growth retardation J:217082
Piezo1tm2.1Apat/Piezo1tm2.1Apat
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA
abnormal calcium ion homeostasis J:229436
abnormal erythrocyte ion transport J:229436
abnormal erythrocyte osmotic lysis J:229436
abnormal spleen morphology J:229436
abnormal splenic cell ratio J:229436
decreased blood osmolality J:229436
decreased circulating haptoglobin level J:229436
decreased erythrocyte cell number J:229436
decreased hematocrit J:229436
decreased mean corpuscular hemoglobin concentration J:229436
increased mean corpuscular hemoglobin J:229436
increased mean corpuscular volume J:229436
increased red blood cell distribution width J:229436
macrocytosis J:229436

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory