Otulin Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Otulin
OTU deubiquitinase with linear linkage specificity
MGI:3577015

28 phenotypes from 5 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Otulin^em1(IMPC)Bay/Otulin⁺ C57BL/6N-Otulin^em1(IMPC)Bay/Bay	abnormal spleen morphology	J:211773
Otulin^em1(IMPC)Bay/Otulin^em1(IMPC)Bay C57BL/6N-Otulin^em1(IMPC)Bay/Bay	prenatal lethality prior to heart atrial septation	J:211773
	preweaning lethality, complete penetrance	J:211773
Otulin^em1Gvl/Otulin^em1Gvl C57BL/6J-Otulin^em1Gvl	prenatal lethality, complete penetrance	J:312394
Otulin^em1Gvl/Otulin^{tm1c(EUCOMM)Hmgu} Tg(KRT14-cre)1Cgn/0 involves: C57BL/6 * C57BL/6J * C57BL/6N * DBA/2	dermatitis	J:312394
	increased squamous cell carcinoma incidence	J:312394
	spontaneous skin ulceration	J:312394
Otulin^m3Sapc/Otulin^m3Sapc C57BL/6J-Otulin^m3Sapc	abnormal blood vessel morphology	J:197674
	abnormal brain vasculature morphology	J:197674
	abnormal facial nerve morphology	J:163657
	abnormal hematopoietic system morphology/development	J:163657
	abnormal internal carotid artery morphology	J:197674
	abnormal vascular endothelial cell migration	J:197674
	abnormal vestibulocochlear nerve morphology	J:163657
	embryonic lethality during organogenesis, complete penetrance	J:197674
	microcephaly	J:163657
	micrognathia	J:163657
	small pharyngeal arch	J:197674
Otulin^m8Sapc/Otulin^m8Sapc Not Specified	abnormal internal carotid artery morphology	J:197674
	embryonic lethality during organogenesis, complete penetrance	J:197674
	small pharyngeal arch	J:197674
Otulin^{tm1c(EUCOMM)Hmgu}/Otulin^{tm1c(EUCOMM)Hmgu} Tg(KRT14-cre)1Cgn/0 involves: C57BL/6 * C57BL/6N * DBA/2	abnormal epidermal stem cell apoptosis	J:312394
	abnormal epidermal stem cell proliferation	J:312394
	abnormal keratinocyte differentiation	J:312394
	dermatitis	J:312394
	normal embryo phenotype	J:312394
	epidermal cyst	J:312394
	epidermal hyperplasia	J:312394
	impaired skin barrier function	J:312394
	increased skin squamous cell carcinoma incidence	J:312394
	sebaceous gland hypertrophy	J:312394
	skin lesions	J:312394
	spontaneous skin ulceration	J:312394

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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