Mdc1 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mdc1
mediator of DNA damage checkpoint 1
MGI:3525201

15 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Mdc1^em1(IMPC)Bay/Mdc1^em1(IMPC)Bay C57BL/6N-Mdc1^em1(IMPC)Bay/BayMmucd	abnormal heart left ventricle morphology	J:211773
	male infertility	J:211773
Mdc1^{Gt(OST441263)Lex}/Mdc1^{Gt(OST441263)Lex} involves: 129S5/SvEvBrd * C57BL/6	abnormal class switch recombination	J:137341
	abnormal double-strand DNA break repair	J:137341
	decreased cell proliferation	J:137341
	decreased litter size	J:137341
	increased cellular sensitivity to ionizing radiation	J:137341
	increased mortality induced by ionizing radiation	J:137341
	male infertility	J:137341
	oligozoospermia	J:137341
	postnatal growth retardation	J:137341
	small seminiferous tubules	J:137341
	small spleen	J:137341
	small testis	J:137341
	small thymus	J:137341
	spontaneous chromosome breakage	J:137341

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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