Palb2 Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Palb2
partner and localizer of BRCA2
MGI:3040695

9 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cdkn1a^tm1Tyj/Cdkn1a^tm1Tyj Palb2^tm1.2Dli/Palb2^tm1.2Dli involves: 129S2/SvPas * 129S4/SvJaeSor * BALB/cJ * C57BL/6	abnormal embryo development	J:197442
	fetal growth retardation	J:197442
	lethality throughout fetal growth and development, complete penetrance	J:197442
Palb2^tm1.1Dli/Palb2^tm1.1Dli Trp53^tm1Brn/Trp53⁺ Tg(KRT14-cre)1Amc/0 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA	decreased tumor latency	J:197442
	increased mammary gland tumor incidence	J:197442
Palb2^tm1.1Dli/Palb2^tm1.1Dli Trp53^tm1Brn/Trp53^tm1Brn Tg(KRT14-cre)1Amc/0 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA	abnormal tumor morphology	J:197442
	decreased tumor latency	J:197442
	increased mammary gland tumor incidence	J:197442
	increased mouth tumor incidence	J:197442
	increased skin tumor incidence	J:197442
Palb2^tm1.1Dli/Palb2^tm1.1Dli Trp53bp1^tm1Jc/Trp53bp1^tm1Jc Cd19^tm1(cre)Cgn/Cd19⁺ involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6	chromosome breakage	J:197442

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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