Palb2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Palb2
partner and localizer of BRCA2
MGI:3040695

23 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Palb2^{Gt(CG0691)Wtsi}/Palb2^{Gt(CG0691)Wtsi} involves: 129P2/OlaHsd * C57BL/6N	abnormal ectoderm development	J:161528
	abnormal embryonic tissue morphology	J:161528
	abnormal embryonic-extraembryonic boundary morphology	J:161528
	abnormal gastrulation	J:161528
	abnormal mesoderm development	J:161528
	abnormal notochord morphology	J:161528
	abnormal tail bud morphology	J:161528
	absent amnion	J:161528
	absent somites	J:161528
	decreased embryo size	J:161528
	decreased inner cell mass proliferation	J:161528
	embryonic lethality between implantation and placentation, incomplete penetrance	J:161528
	embryonic lethality during organogenesis, complete penetrance	J:161528
Palb2^{tm1.1(KOMP)Vlcg}/Palb2⁺ C57BL/6N-Palb2^{tm1.1(KOMP)Vlcg}/J	decreased circulating free fatty acids level	J:211773
	increased circulating insulin level	J:211773
Palb2^{tm1.1(KOMP)Vlcg}/Palb2^{tm1.1(KOMP)Vlcg} C57BL/6N-Palb2^{tm1.1(KOMP)Vlcg}/J	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773
Palb2^tm1.1Dli/Palb2^tm1.1Dli involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6	normal embryo phenotype	J:197442
Palb2^tm1.2Dli/Palb2^tm1.2Dli involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6	abnormal embryo development	J:197442
	abnormal placental labyrinth vasculature morphology	J:197442
	abnormal vitelline vasculature morphology	J:197442
	decreased embryo size	J:197442
	embryonic lethality during organogenesis, complete penetrance	J:197442
	embryonic lethality, incomplete penetrance	J:197442
	exencephaly	J:197442

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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