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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Asxl1
ASXL transcriptional regulator 1
MGI:2684063
27 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background
Annotated Term Reference
Asxl1tm1.1Iaai/Asxl1tm1.1Iaai
Tet2tm1.1Iaai/Tet2tm1.1Iaai
Tg(Mx1-cre)1Cgn/0
involves: 129S/SvEv * C57BL/6 * CBA
abnormal myelopoiesis J:208092
premature death J:208092
Asxl1tm1.1Iaai/Asxl1tm1.1Iaai
Tet2tm1.1Iaai/Tet2tm1.1Iaai
Tg(VAV1-cre)1Graf/0
involves: 129S/SvEv * C57BL/6
normal hematopoietic system phenotype J:208092
Tg(Vav1-Asxl1*Y588X)#Fcy/0
C57BL/6-Tg(Vav1-Asxl1*Y588X)#Fcy
abnormal definitive hematopoiesis J:257690
abnormal hematopoietic stem cell physiology J:257690
abnormal myeloid cell morphology J:257690
abnormal neutrophil morphology J:257690
abnormal spleen morphology J:257690
decreased body weight J:257690
decreased erythrocyte cell number J:257690
decreased hemoglobin content J:257690
decreased leukocyte cell number J:257690
decreased lymphocyte cell number J:257690
decreased megakaryocyte-erythroid progenitor cell number J:257690
enlarged spleen J:257690
hepatosplenomegaly J:257690
increased acute myeloid leukemia incidence J:257690
increased granulocyte monocyte progenitor cell number J:257690
increased hematopoietic stem cell number J:257690
increased leukocyte cell number J:257690
increased megakaryocyte cell number J:257690
increased monocyte cell number J:257690
increased myeloid cell number J:257690
increased myeloid sarcoma incidence J:257690
increased neutrophil cell number J:257690
increased number of Howell-Jolly bodies J:257690
premature death J:257690
thrombocytosis J:257690

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/09/2024
MGI 6.23
The Jackson Laboratory