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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Kmt2d
lysine (K)-specific methyltransferase 2D
MGI:2682319
40 phenotypes from 3 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Kmt2dGt(RRT024)Byg/Kmt2d+
involves: 129P2/OlaHsd * C57BL/6J
abnormal dentate gyrus morphology J:225779
abnormal hippocampus granule cell layer J:225779
abnormal inner ear canal morphology J:225779
abnormal object recognition memory J:225779
decreased body weight J:225779
flattened snout J:225779
impaired contextual conditioning behavior J:225779
impaired spatial learning J:225779
short maxilla J:225779
Kmt2dGt(RRT024)Byg/Kmt2dGt(RRT024)Byg
involves: 129P2/OlaHsd * C57BL/6J
embryonic lethality during organogenesis, complete penetrance J:225779
Kmt2dGt(XT0709)Wtsi/Kmt2dGt(XT0709)Wtsi
involves: 129P2/OlaHsd
embryonic lethality during organogenesis, complete penetrance J:207891
Kmt2dtm1.1Kaig/Kmt2d+
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd * C57BL/6
increased germinal center B cell number J:228913
increased spleen germinal center size J:228913
Kmt2dtm1.1Kaig/Kmt2d+
Tmem163Tg(ACTB-cre)2Mrt/0
B6.Cg-Kmt2dtm1.1Kaig Tg(ACTB-cre)2Mrt
abnormal heart echocardiography feature J:229890
normal cardiovascular system phenotype J:229890
Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd * C57BL/6
abnormal B cell differentiation J:228913
decreased B cell number J:228913
decreased follicular B cell number J:228913
decreased IgG1 level J:228913
decreased IgM level J:228913
decreased mature B cell number J:228913
normal immune system phenotype J:228913
increased B cell proliferation J:228913
increased germinal center B cell number J:228913
increased spleen germinal center number J:228913
increased spleen germinal center size J:228913
Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig
Ighg1tm1(cre)Cgn/Ighg1+
involves: 129P2/OlaHsd * C57BL/6
normal immune system phenotype J:228913
Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig
Mesp1tm2(cre)Ysa/Mesp1+
B6.Cg-Mesp1tm2(cre)Ysa Kmt2dtm1.1Kaig
abnormal heart tube morphology J:229890
embryonic growth retardation J:229890
embryonic lethality during organogenesis, complete penetrance J:229890
pericardial edema J:229890
Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig
Myf5tm3(cre)Sor/Myf5+
involves: 129S4/SvJaeSor * C57BL/6J
abnormal brown fat cell differentiation J:207891
abnormal muscle morphology J:207891
decreased brown adipose tissue amount J:207891
decreased muscle weight J:207891
neonatal lethality, complete penetrance J:207891
respiratory failure J:207891
Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig
Tg(Mef2c-cre)2Blk/0
B6.Cg-Kmt2dtm1.1Kaig Tg(Mef2c-cre)2Blk
abnormal interventricular septum morphology J:229890
embryonic lethality during organogenesis, complete penetrance J:229890
persistent truncus arteriosis J:229890
Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig
Tg(Tnnt2-cre)5Blh/0
B6.Cg-Kmt2dtm1.1Kaig Tg(Tnnt2-cre)5Blh
abnormal fetal cardiomyocyte morphology J:229890
abnormal interventricular septum morphology J:229890
normal cardiovascular system phenotype J:229890
decreased fetal cardiomyocyte proliferation J:229890
embryonic lethality during organogenesis, complete penetrance J:229890
thin myocardium compact layer J:229890
Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig
Tmem163Tg(ACTB-cre)2Mrt/0
B6.Cg-Kmt2dtm1.1Kaig Tg(ACTB-cre)2Mrt
absent head fold J:229890
absent somites J:229890
embryonic lethality between somite formation and embryo turning, complete penetrance J:229890

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory