Nlgn2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nlgn2
neuroligin 2
MGI:2681835

38 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Nlgn2^tm1.1Gchn/Nlgn2^tm1.1Gchn involves: 129S/SvEv * C57BL/6J	abnormal emotion/affect behavior	J:272181
	abnormal hippocampus physiology	J:272181
	abnormal miniature inhibitory postsynaptic currents	J:272181
	abnormal postsynaptic density morphology	J:272181
	abnormal spatial working memory	J:272181
	decreased freezing behavior	J:272181
	decreased miniature inhibitory postsynaptic current amplitude	J:272181
	decreased miniature inhibitory postsynaptic current frequency	J:272181
	decreased prepulse inhibition	J:272181
	decreased startle reflex	J:272181
	impaired contextual conditioning behavior	J:272181
	increased circulating corticosterone level	J:272181
	increased thigmotaxis	J:272181
	induced hyperactivity	J:272181
Nlgn2^tm1.1Sud/Nlgn2^tm1.1Sud involves: C57BL/6NTac	abnormal CNS synaptic transmission	J:229887
	abnormal inhibitory postsynaptic currents	J:229887
	abnormal miniature inhibitory postsynaptic currents	J:229887
	abnormal synapse morphology	J:229887
	normal behavior/neurological phenotype	J:229887
	decreased anxiety-related response	J:229887
	decreased miniature inhibitory postsynaptic current amplitude	J:229887
	decreased miniature inhibitory postsynaptic current frequency	J:229887
	impaired contextual conditioning behavior	J:229887
	impaired cued conditioning behavior	J:229887
	social withdrawal	J:229887
Nlgn2^tm1.1Sud/Nlgn2^tm1.1Sud Tg(Pcp2-cre)2Mpin/? involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac	abnormal inhibitory postsynaptic currents	J:227671
	decreased miniature inhibitory postsynaptic current frequency	J:227671
	increased excitatory postsynaptic current amplitude	J:227671
	normal nervous system phenotype	J:227671
Tg(Thy1-Nlgn2)6Hnes/0 involves: C57BL/6 * CBA	abnormal brain morphology	J:137376
	abnormal brain wave pattern	J:137376
	abnormal response to novelty	J:137376
	abnormal social investigation	J:137376
	normal behavior/neurological phenotype	J:137376
	hyperactivity	J:137376
	increased anxiety-related response	J:137376
	increased miniature inhibitory postsynaptic current frequency	J:137376
	increased startle reflex	J:137376
	increased stereotypic behavior	J:137376
	increased thigmotaxis	J:137376
	increased vertical activity	J:137376
	kyphosis	J:137376
	limb grasping	J:137376
	normal nervous system phenotype	J:137376
	premature death	J:137376
	slow postnatal weight gain	J:137376
	straub tail	J:137376

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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