Mir21a Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mir21a
microRNA 21a
MGI:2676885

21 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Col1a1^{tm2(tetO-LIN28B)Gqda}/Col1a1^{tm3(tetO-Mirlet7g/Mir21)Gqda} Gt(ROSA)26Sor^{tm1(rtTAM2)Jae}/Gt(ROSA)26Sor⁺ involves: 129S4/SvJae C57BL/6 * CD-1	normal homeostasis/metabolism phenotype	J:177113
Col1a1^{tm2(tetO-LIN28B)Gqda}/Col1a1^{tm3(tetO-Mirlet7g/Mir21)Gqda} Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy}/Gt(ROSA)26Sor⁺ Wt1^{tm2(cre/ERT2)Wtp}/Wt1⁺ involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	small kidney	J:211179
Col1a1^{tm3(tetO-Mirlet7g/Mir21)Gqda}/Col1a1⁺ involves: 129S4/SvJae * C57BL/6	decreased neuronal stem cell self-renewal	J:207231
Col1a1^{tm3(tetO-Mirlet7g/Mir21)Gqda}/Col1a1⁺ Gt(ROSA)26Sor^{tm1(rtTAM2)Jae}/Gt(ROSA)26Sor⁺ involves: 129S4/SvJae C57BL/6 * CD-1	decreased body size	J:177113
	impaired glucose tolerance	J:177113
	increased circulating glucose level	J:177113
	increased circulating insulin level	J:177113
	postnatal growth retardation	J:177113
Col1a1^{tm3(tetO-Mirlet7g/Mir21)Gqda}/Col1a1⁺ Myf5^tm1(cre)Mrc/Myf5⁺ involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	decreased body length	J:199720
	decreased body size	J:199720
Col1a1^{tm3(tetO-Mirlet7g/Mir21)Gqda}/? Gt(ROSA)26Sor^{tm1(rtTAM2)Jae}/Gt(ROSA)26Sor⁺ involves: 129S4/SvJae C57BL/6	decreased primordial germ cell number	J:196313
Kras^tm3Tyj/Kras⁺ Mir21a^tm1.1Eno/Mir21a^tm1.1Eno involves: 129S/SvEv * 129S4/SvJae * C57BL/6	decreased lung tumor incidence	J:164198
	decreased tumor growth/size	J:164198
	decreased tumor incidence	J:164198
	increased lung adenoma incidence	J:164198
	increased T cell derived lymphoma incidence	J:164198
	lung epithelium hyperplasia	J:164198
	normal neoplasm	J:164198
Kras^tm3Tyj/Kras⁺ Tg(CAG-Mir21,-EGFP)#Eno/0 involves: 129S4/SvJae * C3H * C57BL/6	decreased tumor incidence	J:164198
	increased lung non-small cell carcinoma incidence	J:164198
	increased lung tumor incidence	J:164198
	increased tumor growth/size	J:164198
	premature death	J:164198

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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