Gpbar1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gpbar1
G protein-coupled bile acid receptor 1
MGI:2653863

26 phenotypes from 6 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gpbar1^em1Gpt/Gpbar1^em1Gpt Tg(Adipoq-cre)1Evdr/0 involves: C57BL/6JGpt * FVB/NJ	decreased physiological sensitivity to xenobiotic	J:325395
Gpbar1^{tm1.1(KOMP)Vlcg}/Gpbar1^{tm1.1(KOMP)Vlcg} C57BL/6N-Gpbar1^{tm1.1(KOMP)Vlcg}/Ucd	abnormal heart morphology	J:211773
	abnormal kidney morphology	J:211773
	abnormal lymph node morphology	J:211773
	abnormal testis morphology	J:211773
	enlarged heart	J:211773
	increased circulating alanine transaminase level	J:211773
	small testis	J:211773
Gpbar1^tm1.2Auw/Gpbar1^tm1.2Auw involves: 129 * C57BL/6J	decreased physiological sensitivity to xenobiotic	J:152388
	impaired glucose tolerance	J:152388
	increased circulating insulin level	J:152388
Gpbar1^tm1Gvas/Gpbar1^tm1Gvas involves: 129S1/SvImJ * C57BL/6	abnormal bile composition	J:115877
	abnormal bile duct development	J:115877
	abnormal cholesterol homeostasis	J:115877
	abnormal gallbladder morphology	J:115877
	gallstones	J:115877
	normal liver/biliary system phenotype	J:115877
Gpbar1^tm1Ktan/Gpbar1⁺ involves: 129X1/SvJ * C57BL/6N	abnormal adipose tissue amount	J:114971
Gpbar1^tm1Ktan/Gpbar1⁺ involves: 129X1/SvJ * C57BL/6N	increased susceptibility to weight gain	J:114971
Gpbar1^tm1Ktan/Gpbar1^tm1Ktan involves: 129X1/SvJ * C57BL/6N	abnormal adipose tissue amount	J:114971
	abnormal bile salt homeostasis	J:114971
	increased circulating cholesterol level	J:114971
	increased susceptibility to weight gain	J:114971
Tg(Gpbar1)1Auw/0 involves: C57BL/6J	abnormal pancreatic islet size	J:152388
	decreased locomotor activity	J:152388
	decreased respiratory quotient	J:152388
	improved glucose tolerance	J:152388
	increased circulating insulin level	J:152388
	increased insulin secretion	J:152388
	increased oxygen consumption	J:152388

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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