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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Tph2
tryptophan hydroxylase 2
MGI:2651811
40 phenotypes from 12 alleles in 15 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Tph2Arg447/Tph2Arg447
BALB/cJ
abnormal serotonin level J:94745
Tph2Arg447/Tph2Arg447
DBA/2J
abnormal serotonin level J:94745
Tph2Pro447/Tph2Pro447
129X1/SvJ
abnormal serotonin level J:94745
Tph2Pro447/Tph2Pro447
C57BL/6J
abnormal serotonin level J:94745
Tph2tm1.1Zfc/Tph2tm1.1Zfc
involves: 129S7/SvEvBrd
abnormal mating preference J:170988
decreased serotonin level J:170988
Tph2tm1.2Kpl/Tph2tm1.2Kpl
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
abnormal serotonergic neuron morphology J:150637
normal mortality/aging J:150637
normal nervous system phenotype J:150637
Tph2tm1Bdr/Tph2tm1Bdr
B6.129P2-Tph2tm1Bdr
abnormal skin condition J:150042
decreased body size J:150042
decreased circulating insulin-like growth factor I level J:150042
postnatal growth retardation J:150042
premature death J:150042
weakness J:150042
Tph2tm1Bdr/Tph2tm1Bdr
FVB.129P2-Tph2tm1Bdr
abnormal circadian regulation of heart rate J:150042
abnormal circadian regulation of systemic arterial blood pressure J:150042
abnormal skin condition J:150042
abnormal sleep pattern J:150042
decreased body size J:150042
decreased circulating insulin-like growth factor I level J:150042
decreased pulmonary respiratory rate J:150042
postnatal growth retardation J:150042
premature death J:150042
weakness J:150042
Tph2tm1Bdr/Tph2tm1Bdr
involves: 129P2/OlaHsd * FVB/N
abnormal autonomic nervous system physiology J:150042
abnormal circadian regulation of heart rate J:150042
abnormal circadian regulation of systemic arterial blood pressure J:150042
abnormal maternal nurturing J:150042
abnormal pup retrieval J:150042
abnormal skin condition J:150042
abnormal sleep pattern J:150042
decreased body size J:150042
decreased body weight J:150042
decreased circulating insulin-like growth factor I level J:150042
decreased pulmonary respiratory rate J:150042
decreased serotonin level J:150042
impaired adaptive thermogenesis J:150042
increased aggression J:150042
increased aggression towards females J:150042
induced hyperactivity J:150042
postnatal growth retardation J:150042
premature death J:150042
pup cannibalization J:150042
normal taste/olfaction phenotype J:150042
Tph2tm1Dmkh/Tph2tm1Dmkh
involves: C57BL/6
decreased serotonin level J:196205
increased core body temperature J:196205
normal nervous system phenotype J:196205
Tph2tm1Lex/Tph2tm1Lex
involves: 129S5/SvEvBrd * C57BL/6J
abnormal emotion/affect behavior J:144582
abnormal response to novel object J:144582
decreased body length J:144582
decreased body weight J:144582
decreased serotonin level J:144582
Tph2tm1Mca/Tph2+
involves: 129S6/SvEvTac * C57BL/6J
decreased coping response J:131619
decreased serotonin level J:131619
increased aggression towards males J:131619
increased anxiety-related response J:131619
Tph2tm1Mca/Tph2tm1Mca
involves: 129S6/SvEvTac * C57BL/6J
abnormal nervous system electrophysiology J:196373
decreased coping response J:131619, J:196373
decreased serotonin level J:131619
increased aggression towards males J:131619
increased anxiety-related response J:131619
Tph2tm1Pasq/Tph2tm1.1Pasq
involves: 129P2/OlaHsd * C57BL/6 * SJL
abnormal hippocampus morphology J:188987
abnormal paraventricular hypothalamic nucleus morphology J:188987
abnormal suprachiasmatic nucleus morphology J:188987
normal nervous system phenotype J:188987
Tph2tm1Pasq/Tph2tm1Pasq
either: (involves: 129P2/OlaHsd * C57BL/6) or B6.129P2-Tph2tm1Pasq
normal behavior/neurological phenotype J:188987
postnatal growth retardation J:188987
postnatal lethality, incomplete penetrance J:188987
Tph2tm2.1Pasq/Tph2tm2.1Pasq
B6.129P2(SJL)-Tph2tm2.1Pasq
no abnormal phenotype detected J:238619
Tph2tm2.1Pasq/Tph2tm2.2Pasq
Tg(CMV-cre/ERT)1Ipc/0
involves: 129P2/OlaHsd * C57BL/6 * SJL
decreased serotonin level J:238619
Tph2tm2.2Pasq/Tph2tm2.2Pasq
involves: 129P2/OlaHsd * C57BL/6 * SJL
decreased body weight J:238619
decreased serotonin level J:238619
postnatal lethality, incomplete penetrance J:238619

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/18/2019
MGI 6.14
The Jackson Laboratory