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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Disc1
disrupted in schizophrenia 1
MGI:2447658
56 phenotypes from 9 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Disc1del/Disc1del
B6.129S6-Disc1del
abnormal learning/memory/conditioning J:107244
Disc1em1(IMPC)Mbp/Disc1em1(IMPC)Mbp
C57BL/6N-Disc1em1(IMPC)Mbp/MbpMmucd
abnormal heart morphology J:211773
abnormal kidney morphology J:211773
abnormal spleen morphology J:211773
abnormal vitreous body morphology J:211773
cataract J:211773
enlarged heart J:211773
hyperactivity J:211773
increased prepulse inhibition J:211773
small kidney J:211773
Disc1m1H/Disc1m1H
B6N.C(C3H)-Disc1m1H
abnormal social investigation J:229661
normal behavior/neurological phenotype J:229661
decreased exploration in new environment J:229661
decreased vertical activity J:229661
impaired passive avoidance behavior J:229661
increased anxiety-related response J:229661
increased locomotor activity J:229661
increased thigmotaxis J:229661
Disc1Rgsc1390/Disc1+
B6.Cg-Disc1Rgsc1390
abnormal entorhinal cortex morphology J:120634
abnormal latent inhibition of conditioning behavior J:120634
abnormal prepulse inhibition J:120634
normal behavior/neurological phenotype J:120634
decreased brain size J:120634
decreased startle reflex J:120634
small cerebellum J:120634
small thalamus J:120634
thin cerebral cortex J:120634
Disc1Rgsc1390/Disc1Rgsc1390
B6.Cg-Disc1Rgsc1390
abnormal entorhinal cortex morphology J:120634
abnormal latent inhibition of conditioning behavior J:120634
abnormal prepulse inhibition J:120634
abnormal spatial learning J:120634
abnormal spatial working memory J:120634
normal behavior/neurological phenotype J:120634
decreased brain size J:120634
decreased startle reflex J:120634
increased exploration in new environment J:120634
small cerebellum J:120634
small thalamus J:120634
thin cerebral cortex J:120634
Disc1Rgsc1390/Disc1Rgsc1393
B6.Cg-Disc1Rgsc1390/Disc1Rgsc1393
abnormal prepulse inhibition J:120634
decreased startle reflex J:120634
Disc1Rgsc1393/Disc1+
B6.Cg-Disc1Rgsc1393
abnormal entorhinal cortex morphology J:120634
abnormal social/conspecific interaction behavior J:120634
decreased brain size J:120634
normal nervous system phenotype J:120634
small cerebellum J:120634
small thalamus J:120634
thin cerebral cortex J:120634
Disc1Rgsc1393/Disc1Rgsc1393
B6.Cg-Disc1Rgsc1393
abnormal entorhinal cortex morphology J:120634
abnormal latent inhibition of conditioning behavior J:120634
abnormal liquid preference J:120634
abnormal prepulse inhibition J:120634
abnormal social/conspecific interaction behavior J:120634
abnormal spatial working memory J:120634
normal behavior/neurological phenotype J:120634
behavioral despair J:120634
decreased brain size J:120634
small cerebellum J:120634
small thalamus J:120634
thin cerebral cortex J:120634
Disc1tm1Kara/Disc1+
B6.129S6-Disc1tm1Kara
abnormal learning/memory/conditioning J:107244
Disc1tm1Kara/Disc1tm1Kara
B6.129S6-Disc1tm1Kara
abnormal learning/memory/conditioning J:107244
Disc1tm1Kozo/Disc1tm1Kozo
B6JJmsSlc.Cg-Disc1tm1Kozo
abnormal impulsive behavior control J:177560
abnormal long-term potentiation J:177560
abnormal response to novel object J:177560
abnormal social investigation J:177560
abnormal synaptic depression J:177560
normal behavior/neurological phenotype J:177560
decreased anxiety-related response J:177560
decreased prepulse inhibition J:177560
decreased serotonin level J:177560
enhanced contextual conditioning behavior J:177560
increased locomotor activity J:177560
induced hyperactivity J:177560
normal nervous system phenotype J:177560
reduced long-term potentiation J:177560
Tg(Camk2a-ESR1/Disc1*)2698.1Sva/0
involves: C57BL/6 * C57BL/6NTac
abnormal CNS synaptic transmission J:127235
abnormal dendrite morphology J:127235
abnormal neuron morphology J:127235
abnormal social investigation J:127235
abnormal spatial working memory J:127235
behavioral despair J:127235
social withdrawal J:127235
Tg(Disc1/EGFP)M19Sshe/0
involves: C57BL/6JCrl * CBA/CaCrl
abnormal axon extension J:143557
abnormal brain interneuron morphology J:143557
abnormal latent inhibition of conditioning behavior J:143557
abnormal neurite morphology J:143557
abnormal neuron proliferation J:143557
behavioral despair J:143557
decreased brain size J:143557
decreased corpus callosum size J:143557
decreased neuron number J:143557
decreased vocalization J:143557
dilated lateral ventricle J:143557
enlarged lateral ventricles J:143557
thin cerebral cortex J:143557

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory