Ago2 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ago2
argonaute RISC catalytic subunit 2
MGI:2446632

23 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Ago1^tm1.1Tara/Ago1^tm1.1Tara Ago2^tm1.1Tara/Ago2^tm1.1Tara Tg(KRT14-cre)1Efu/0 involves: 129P2/OlaHsd	abnormal hair follicle development	J:183622
	abnormal hair follicle morphology	J:183622
	abnormal skin physiology	J:183622
	epidermal cyst	J:183622
	hair follicle degeneration	J:183622
	sparse hair	J:183622
	thick epidermis	J:183622
Ago2^tm1.1Tara/Ago2^tm1.1Tara Lep^ob/Lep^ob Tg(Ins2-cre)23Herr/0 involves: 129P2/OlaHsd * C57BL/6J * CBA/J	decreased circulating glucose level	J:210552
	decreased circulating insulin level	J:210552
	normal endocrine/exocrine gland phenotype	J:210552
	improved glucose tolerance	J:210552
	increased circulating insulin level	J:210552
	increased pancreatic beta cell mass	J:210552
	increased pancreatic beta cell number	J:210552
Ago2^tm1Ghan/Ago2^tm1Ghan involves: C57BL/6	abnormal forebrain development	J:93081
	abnormal placenta morphology	J:93081
	abnormal visceral yolk sac morphology	J:93081
	embryonic growth retardation	J:93081
	enlarged heart	J:93081
	open neural tube	J:93081
	pericardial edema	J:93081
	prenatal lethality, complete penetrance	J:93081
	wavy neural tube	J:93081

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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