Malt1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Malt1
MALT1 paracaspase
MGI:2445027

14 phenotypes from 5 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Malt1^m1Btlr/Malt1⁺ C57BL/6J-Malt1^m1Btlr	impaired humoral immune response	J:221474
Malt1^m1Btlr/Malt1^m1Btlr C57BL/6J-Malt1^m1Btlr	impaired humoral immune response	J:221474
Malt1^m2Btlr/Malt1⁺ C57BL/6J-Malt1^m2Btlr	decreased IgM level	J:224671
Malt1^m2Btlr/Malt1⁺ C57BL/6J-Malt1^m2Btlr	impaired humoral immune response	J:224671
Malt1^m2Btlr/Malt1^m2Btlr C57BL/6J-Malt1^m2Btlr	decreased IgG level	J:224671
	decreased IgM level	J:224671
	impaired humoral immune response	J:224671
Malt1^m3Btlr/Malt1⁺ C57BL/6J-Malt1^m3Btlr	decreased IgM level	J:224672
Malt1^m3Btlr/Malt1⁺ C57BL/6J-Malt1^m3Btlr	impaired humoral immune response	J:224672
Malt1^m3Btlr/Malt1^m3Btlr C57BL/6J-Malt1^m3Btlr	decreased IgG level	J:224672
	decreased IgM level	J:224672
	impaired humoral immune response	J:224672
Malt1^tm1Mak/Malt1^tm1Mak involves: 129P2/OlaHsd	abnormal dendritic cell physiology	J:111706
	decreased IgG level	J:109545
	decreased IgM level	J:109545
	decreased T cell proliferation	J:109545
Malt1^tm1Vmd/Malt1^tm1Vmd involves: C57BL/6N	abnormal B cell differentiation	J:86770
	abnormal double-negative T cell morphology	J:86770
	abnormal immune system morphology	J:86770
	abnormal spleen marginal zone morphology	J:86770
	abnormal T cell differentiation	J:86770
	abnormal T cell proliferation	J:86770
	absent B-1a cells	J:86770
	decreased immunoglobulin level	J:86770
	decreased interleukin-2 secretion	J:86770

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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