48 phenotypes from 6 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tet2Gt(AN0709)Wtsi/Tet2+ B6.129P2-Tet2Gt(AN0709)Wtsi	abnormal monocyte differentiation	J:174052
	abnormal spleen morphology	J:174052
	anemia	J:174052
	decreased erythrocyte cell number	J:174052
	enlarged liver	J:174052
	enlarged spleen	J:174052
	increased B cell number	J:174052
	increased erythroid progenitor cell number	J:174052
	increased leukocyte cell number	J:174052
	increased monocyte cell number	J:174052
	liver fibrosis	J:174052
	liver inflammation	J:174052
	premature death	J:174052
	thrombocytopenia	J:174052
	weight loss	J:174052
Tet2Gt(AN0709)Wtsi/Tet2Gt(AN0709)Wtsi B6.129P2-Tet2Gt(AN0709)Wtsi	abnormal common myeloid progenitor cell morphology	J:174052
	abnormal monocyte differentiation	J:174052
	abnormal spleen morphology	J:174052
	anemia	J:174052
	decreased erythrocyte cell number	J:174052
	decreased pre-B cell number	J:174052
	decreased pro-B cell number	J:174052
	enlarged liver	J:174052
	enlarged spleen	J:174052
	extramedullary hematopoiesis	J:174052
	increased B cell number	J:174052
	increased DN1 thymic pro-T cell number	J:174052
	increased double-negative T cell number	J:174052
	increased erythroid progenitor cell number	J:174052
	increased hematopoietic stem cell number	J:174052
	increased leukocyte cell number	J:174052
	increased monocyte cell number	J:174052
	liver inflammation	J:174052
	premature death	J:174052
	thrombocytopenia	J:174052
	weight loss	J:174052
Tet2Gt(Ayu17-449)Imeg/Tet2Gt(Ayu17-449)Imeg involves: C57BL/6 * CBA	abnormal proximal convoluted tubule morphology	J:140275
	neonatal lethality, incomplete penetrance	J:140275
	postnatal lethality	J:140275
Tet2tm1.1Iaai/Tet2+ Tg(VAV1-cre)1Graf/0 involves: 129S/SvEv * C57BL/6	abnormal hematopoietic stem cell physiology	J:174053
	extramedullary hematopoiesis	J:174053
	increased hematopoietic cell number	J:174053
	increased leukocyte cell number	J:174053
	increased monocyte cell number	J:174053
Tet2tm1.1Iaai/Tet2tm1.1Iaai Tg(EIIa-cre)C5379Lmgd/0 involves: 129S/SvEv * C57BL/6 * FVB/N	no abnormal phenotype detected	J:174053
Tet2tm1.1Iaai/Tet2tm1.1Iaai Tg(Mx1-cre)1Cgn/0 involves: 129S/SvEv * C57BL/6 * CBA	abnormal erythropoiesis	J:234976
	abnormal hematopoietic stem cell physiology	J:174053
	abnormal myelopoiesis	J:234976
	decreased B cell number	J:234976
	enlarged spleen	J:234976
	increased granulocyte number	J:234976
	increased hematopoietic stem cell number	J:234976
	premature death	J:208092
Tet2tm1.1Iaai/Tet2tm1.1Iaai Tg(VAV1-cre)1Graf/0 involves: 129S/SvEv * C57BL/6	abnormal common myeloid progenitor cell morphology	J:174053
	abnormal hematopoietic stem cell physiology	J:174053
	abnormal myeloid leukocyte morphology	J:174053
	enlarged spleen	J:174053
	extramedullary hematopoiesis	J:174053
	increased chronic myelocytic leukemia incidence	J:174053
	increased hematopoietic cell number	J:174053
	increased leukocyte cell number	J:174053
	increased monocyte cell number	J:174053
	increased spleen weight	J:174053
	myeloid hyperplasia	J:174053
Tet2tm1.1Mjxu/Tet2+ involves: 129 * C57BL/6	enlarged spleen	J:178415
	increased chronic myelocytic leukemia incidence	J:178415
	increased leukemia incidence	J:178415
	increased leukocyte cell number	J:178415
	increased monocyte cell number	J:178415
	myeloid hyperplasia	J:178415
	premature death	J:178415
Tet2tm1.1Mjxu/Tet2tm1.1Mjxu involves: 129 * C57BL/6	abnormal common myeloid progenitor cell morphology	J:178415
	abnormal hematopoietic stem cell physiology	J:178415
	anemia	J:178415
	enlarged liver	J:178415
	enlarged spleen	J:178415
	increased bone marrow cell number	J:178415
	increased chronic myelocytic leukemia incidence	J:178415
	increased erythrocyte cell number	J:178415
	increased hematopoietic stem cell number	J:178415
	increased hemoglobin content	J:178415
	increased leukemia incidence	J:178415
	increased leukocyte cell number	J:178415
	increased monocyte cell number	J:178415
	increased neutrophil cell number	J:178415
	myeloid hyperplasia	J:178415
	premature death	J:178415
Tet2tm1.2Rao/Tet2tm1.2Rao involves: C57BL/6NTac	abnormal definitive hematopoiesis	J:175222
	abnormal myelopoiesis	J:175222
	increased bone marrow cell number	J:175222
	increased hematopoietic stem cell number	J:175222
	increased splenocyte number	J:175222
Tet2tm1Ics/Tet2tm1Ics Tg(Mx1-cre)1Cgn/0 involves: C57BL/6 * CBA	abnormal common myeloid progenitor cell morphology	J:174052
	abnormal liver sinusoid morphology	J:174052
	abnormal proerythroblast morphology	J:174052
	abnormal spleen morphology	J:174052
	decreased erythrocyte cell number	J:174052
	decreased pre-B cell number	J:174052
	decreased pro-B cell number	J:174052
	enlarged liver	J:174052
	enlarged spleen	J:174052
	extramedullary hematopoiesis	J:174052
	increased B cell number	J:174052
	increased DN1 thymic pro-T cell number	J:174052
	increased double-negative T cell number	J:174052
	increased erythroblast number	J:174052
	increased hematopoietic stem cell number	J:174052
	increased leukocyte cell number	J:174052
	increased monocyte cell number	J:174052
	increased spleen red pulp amount	J:174052
	normal mortality/aging	J:174052
	thrombocytopenia	J:174052