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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Mib1
MIB E3 ubiquitin protein ligase 1
MGI:2443157
70 phenotypes from 4 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Mib1em1Jlp/Mib1tm2Kong
Tg(Tnnt2-cre)5Blh/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2
abnormal aortic valve morphology J:338889
abnormal cardiac outflow tract development J:338889
abnormal trabecula carnea morphology J:338889
aortic valve regurgitation J:338889
bicuspid aortic valve J:338889
cardiac fibrosis J:338889
decreased cardiac muscle contractility J:338889
dilated heart ventricle J:338889
lethality during fetal growth through weaning, incomplete penetrance J:338889
thin left ventricle myocardium compact layer J:338889
Mib1tm1Art/Mib1tm1Art
BTNTTFArt.129S-Mib1tm1Art
abnormal blood vessel morphology J:102528
abnormal embryonic neuroepithelial layer differentiation J:102528
abnormal embryonic neuroepithelium morphology J:102528
abnormal heart looping J:102528
abnormal rostral-caudal axis patterning J:102528
abnormal somite shape J:102528
abnormal vitelline vasculature morphology J:102528
absent second pharyngeal arch J:102528
embryonic lethality during organogenesis, complete penetrance J:102528
failure of chorioallantoic fusion J:102528
failure of somite differentiation J:102528
incomplete somite formation J:102528
kinked neural tube J:102528
pericardial edema J:102528
premature neuronal precursor differentiation J:102528
Mib1tm1Kong/Mib1tm1Kong
either: B6.129P2-Mib1tm1Kong or (involves: 129P2/OlaHsd * FVB/N)
abnormal angiogenesis J:101173
abnormal blood circulation J:101173
abnormal dorsal aorta morphology J:101173
abnormal dorsal-ventral polarity of the somites J:101173
abnormal intersomitic vessel morphology J:101173
abnormal neural tube morphology J:101173
abnormal notochord morphology J:101173
abnormal paraxial mesoderm morphology J:101173
abnormal vascular regression J:101173
abnormal visceral yolk sac morphology J:101173
abnormal vitelline vascular remodeling J:101173
absent intersomitic vessels J:101173
absent second pharyngeal arch J:101173
caudal body truncation J:101173
distended pericardium J:101173
embryonic growth retardation J:101173
embryonic lethality during organogenesis, complete penetrance J:101173
failure of heart looping J:101173
fused somites J:101173
kinked neural tube J:101173
poor arterial differentiation J:101173
premature neuronal precursor differentiation J:101173
small heart J:101173
Mib1tm1Kong/Mib1tm1Kong
involves: 129P2/OlaHsd
abnormal aorta morphology J:137915
abnormal definitive hematopoiesis J:137915
Mib1tm1Kong/Mib1tm1Kong
involves: 129P2/OlaHsd * C57BL/6
embryonic lethality J:130369
Mib1tm2Kong/Mib1tm2Kong
Foxa2tm3.1(icre)Heli/Foxa2+
involves: 129P2/OlaHsd * C57BL/6 * SJL
abnormal pancreas development J:184814
abnormal pancreatic beta cell differentiation J:184814
absent pancreatic duct J:184814
Mib1tm2Kong/Mib1tm2Kong
Tg(GFAP-cre)25Mes/0
involves: 129P2/OlaHsd * C57BL/6 * FVB/N
abnormal cerebellum external granule cell layer morphology J:130369
abnormal CNS glial cell morphology J:130369
abnormal neuronal migration J:130369
decreased body size J:130369
premature death J:130369
reduced cerebellar foliation J:130369
small cerebellum J:130369
Mib1tm2Kong/Mib1tm2Kong
Tg(Msx2-cre)5Rem/0
involves: 129P2/OlaHsd * C57BL/6
abnormal digit development J:130369
abnormal epidermal layer morphology J:130369
abnormal interdigital cell death J:130369
decreased body size J:130369
decreased hair follicle number J:130369
epidermal cyst J:130369
fused phalanges J:130369
hairless J:130369
premature hair loss J:130369
syndactyly J:130369
thick epidermis J:130369
Mib1tm2Kong/Mib1tm2Kong
Tg(Tek-cre)12Flv/0
involves: 129P2/OlaHsd * C3H * C57BL/6
abnormal definitive hematopoiesis J:137915
abnormal dorsal aorta morphology J:130369
abnormal vascular regression J:130369
abnormal vitelline vascular remodeling J:130369
absent vitelline blood vessels J:130369
normal cardiovascular system phenotype J:130369
embryonic growth retardation J:130369
embryonic lethality during organogenesis, complete penetrance J:130369
pericardial effusion J:130369

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory