Abcc4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Abcc4
ATP-binding cassette, sub-family C member 4
MGI:2443111

20 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Abcc4^{Gt(RRC212)Byg}/Abcc4^{Gt(RRC212)Byg} involves: 129P2/OlaHsd * C57BL/6	decreased prostaglandin level	J:139829
	increased chemical nociceptive threshold	J:139829
	increased thermal nociceptive threshold	J:139829
Abcc4^tm1Jsch/Abcc4^tm1Jsch involves: 129X1/SvJ	abnormal blood-brain barrier function	J:92788
	abnormal blood-cerebrospinal fluid barrier function	J:92788
	abnormal urine organic anion level	J:92788
Abcc4^tm1Kruh/Abcc4^tm1Kruh B6.129-Abcc4^tm1Kruh	abnormal blood homeostasis	J:117326
	abnormal blood-brain barrier function	J:117326
	abnormal intestinal mucosa morphology	J:117326
	abnormal small intestine morphology	J:117326
	abnormal spleen B cell follicle morphology	J:117326
	abnormal spleen red pulp morphology	J:117326
	decreased spleen B cell follicle number	J:117326
	decreased spleen B cell follicle size	J:117326
	increased susceptibility to induced colitis	J:117326
	increased susceptibility to induced morbidity/mortality	J:117326
	intestinal inflammation	J:117326
	small intestinal inflammation	J:117326
	small spleen	J:117326
	thymus cortex hypoplasia	J:117326
	weight loss	J:117326

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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