Rc3h2 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rc3h2
ring finger and CCCH-type zinc finger domains 2
MGI:2442789

20 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Rc3h1^san/Rc3h1^san Rc3h2^tm1.2Cgv/Rc3h2^tm1.2Cgv involves: C57BL/6 * C57BL/6JSfdAnu	increased circulating tumor necrosis factor level	J:196137
	increased inflammatory response	J:196137
	increased susceptibility to bacterial infection	J:196137
	increased T follicular helper cell number	J:196137
	kidney inflammation	J:196137
	premature death	J:196137
Rc3h1^tm1.1Mass/Rc3h1^tm1.1Mass Rc3h2^{tm1c(KOMP)Wtsi}/Rc3h2^{tm1c(KOMP)Wtsi} Tg(Cd4-cre)1Cwi/? involves: C57BL/6N * DBA/2	abnormal B cell number	J:196136
	abnormal immune system cell morphology	J:196136
	abnormal immune system organ morphology	J:196136
	abnormal immune system physiology	J:196136
	abnormal spleen B cell follicle morphology	J:196136
	abnormal spleen morphology	J:196136
	abnormal spleen periarteriolar lymphoid sheath morphology	J:196136
	decreased CD4-positive, alpha-beta T cell number	J:196136
	decreased CD8-positive, alpha-beta T cell number	J:196136
	decreased T cell number	J:196136
	enlarged lymph nodes	J:196136
	enlarged spleen	J:196136
	increased germinal center B cell number	J:196136
	increased T cell proliferation	J:196136
	increased T follicular helper cell number	J:196136

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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