Slc30a8 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Slc30a8
solute carrier family 30 (zinc transporter), member 8
MGI:2442682

15 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Slc30a8^tm1.1Geno/Slc30a8^tm1.1Geno involves: 129/Sv * C57BL/6JRj	abnormal pancreatic beta cell physiology	J:153253
	abnormal zinc homeostasis	J:153253
	decreased insulin secretion	J:153253
	impaired glucose tolerance	J:153253
	increased circulating glucose level	J:153253
	increased susceptibility to diet-induced obesity	J:153253
Slc30a8^tm1.1Htwt/Slc30a8^tm1.1Htwt Tg(Ins2-cre)25Mgn/0 involves: C57BL/6 * CBA/JNCrlj * DBA	abnormal insulin clearance	J:204003
	abnormal pancreatic beta cell morphology	J:204003
	abnormal zinc homeostasis	J:204003
	normal homeostasis/metabolism phenotype	J:204003
	impaired glucose tolerance	J:204003
	increased insulin secretion	J:204003
	normal liver/biliary system phenotype	J:204003
Slc30a8^{tm1a(KOMP)Wtsi}/Slc30a8^{tm1a(KOMP)Wtsi} C57BL/6N-Slc30a8^{tm1a(KOMP)Wtsi}/Wtsi	increased circulating aspartate transaminase level	J:175295
	increased hemoglobin content	J:175295
	increased mean corpuscular hemoglobin	J:175295
Slc30a8^tm1Lex/Slc30a8^tm1Lex involves: 129S6/SvEvTac * C57BL/6	abnormal zinc homeostasis	J:152629
	decreased circulating insulin level	J:152629
	decreased insulin secretion	J:152629
	normal homeostasis/metabolism phenotype	J:152629

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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