Gpr68 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gpr68
G protein-coupled receptor 68
MGI:2441763

24 phenotypes from 5 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gpr68^tm1.1Aha/Gpr68^tm1.1Aha B6.129(C)-Gpr68^tm1.1Aha	decreased circulating insulin level	J:189192
	decreased insulin secretion	J:189192
	normal endocrine/exocrine gland phenotype	J:189192
Gpr68^tm1.1Yaxu/Gpr68^tm1.1Yaxu B6.Cg-Gpr68^tm1.1Yaxu	abnormal osteoclast differentiation	J:149315
	abnormal osteoclast physiology	J:149315
	normal adipose tissue phenotype	J:149315
	decreased tumor growth/size	J:149315
	normal immune system phenotype	J:149315
	normal skeleton phenotype	J:149315
Gpr68^tm1.1Yaxu/Gpr68^tm1.1Yaxu involves: 129S4/SvJae * C57BL/6 * FVB/N	abnormal brown adipose tissue morphology	J:149315
	abnormal macrophage physiology	J:149315
	abnormal osteoclast differentiation	J:149315
	abnormal osteoclast physiology	J:149315
	decreased macrophage cell number	J:149315
	decreased tumor growth/size	J:149315
	increased brown adipose tissue amount	J:149315
	increased monocyte cell number	J:149315
	normal skeleton phenotype	J:149315
Gpr68^tm1Aha/Gpr68^tm1Aha B6.129-Gpr68^tm1Aha	decreased circulating glucagon level	J:189192
	decreased circulating glucose level	J:189192
	decreased circulating insulin level	J:189192
	decreased insulin secretion	J:189192
	normal endocrine/exocrine gland phenotype	J:189192
	normal homeostasis/metabolism phenotype	J:189192
	normal immune system phenotype	J:146233
	increased insulin sensitivity	J:189192
Gpr68^tm1Dgen/Gpr68^tm1Dgen B6.129P2-Gpr68^tm1Dgen	abnormal kidney physiology	J:232321
	normal renal/urinary system phenotype	J:232321
	normal respiratory system phenotype	J:224758
Gpr68^tm1Yaxu/Gpr68^tm1Yaxu involves: C57BL/6	abnormal brown adipose tissue morphology	J:149315
	abnormal macrophage physiology	J:149315
	abnormal osteoclast differentiation	J:149315
	abnormal osteoclast physiology	J:149315
	decreased brown adipose tissue amount	J:149315
	decreased monocyte cell number	J:149315
	increased tumor growth/size	J:149315

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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