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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Supv3l1
suppressor of var1, 3-like 1 (S. cerevisiae)
MGI:2441711
57 phenotypes from 7 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Supv3l1tm1a(EUCOMM)Wtsi/Supv3l1tm1a(EUCOMM)Wtsi
B6Brd;B6Dnk;B6N-Tyrc-Brd Supv3l1tm1a(EUCOMM)Wtsi/Wtsi 		preweaning lethality, complete penetrance J:211773
Supv3l1tm1Jkl/Supv3l1+
involves: 129S7/SvEvBrd * C57BL/6 		decreased survivor rate J:141467
embryonic lethality during organogenesis, incomplete penetrance J:141467
transmission ratio distortion J:141467
Supv3l1tm1Jkl/Supv3l1tm1Jkl
involves: 129S7/SvEvBrd * C57BL/6 		abnormal craniofacial development J:141467
abnormal embryo development J:141467
embryonic lethality during organogenesis, complete penetrance J:141467
Supv3l1tm1Whle/Supv3l1+
involves: 129P2/OlaHsd * C57BL/6 		maternal effect J:193361
Supv3l1tm1Whle/Supv3l1tm1Whle
involves: 129P2/OlaHsd * C57BL/6 		absent egg cylinders J:193361
decreased embryo size J:193361
embryonic growth retardation J:193361
embryonic lethality between implantation and placentation, incomplete penetrance J:193361
embryonic lethality during organogenesis, complete penetrance J:193361
Supv3l1tm2.1Jkl/Supv3l1tm2.1Jkl
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 		no abnormal phenotype detected J:144991
Supv3l1tm2.1Jkl/Supv3l1tm2.2Jkl
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB/N 		abnormal dermal layer morphology J:144991
abnormal duodenum morphology J:144991
abnormal epidermis stratum granulosum morphology J:144991
abnormal locomotor behavior J:144991
abnormal lung interstitium morphology J:144991
abnormal skin morphology J:144991
abnormal T cell differentiation J:144991
acanthosis J:144991
cachexia J:144991
decreased body weight J:144991
decreased CD4-positive, alpha-beta T cell number J:144991
decreased CD8-positive, alpha-beta T cell number J:144991
decreased double-negative T cell number J:144991
decreased double-positive T cell number J:144991
decreased sebaceous gland number J:144991
decreased skeletal muscle mass J:144991
decreased subcutaneous adipose tissue amount J:144991
dilated vasculature J:144991
dystrophic muscle J:144991
hyperkeratosis J:144991
increased macrophage derived foam cell number J:144991
normal integument phenotype J:144991
kyphosis J:144991
lung inflammation J:144991
parakeratosis J:144991
premature death J:144991
reddish skin J:144991
scaly skin J:144991
thick epidermis J:144991
thymus atrophy J:144991
thymus hypoplasia J:144991
Supv3l1tm2.1Jkl/Supv3l1tm2.2Jkl
Tg(KRT14-cre/ERT)20Efu/0
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CD-1 * FVB/N 		abnormal dermal layer morphology J:144991
acanthosis J:144991
normal adipose tissue phenotype J:144991
dilated vasculature J:144991
hyperkeratosis J:144991
normal integument phenotype J:144991
parakeratosis J:144991
reddish skin J:144991
scaly skin J:144991
thick epidermis J:144991
Supv3l1tm2.2Jkl/Supv3l1tm2.2Jkl
involves: 129P2/OlaHsd * C57BL/6 * FVB/N 		prenatal lethality, complete penetrance J:144991
Supv3l1tm2.3Jkl/Supv3l1tm2.3Jkl
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB/N 		prenatal lethality, complete penetrance J:144991
Supv3l1tm2Jkl/Supv3l1tm2Jkl
involves: 129P2/OlaHsd * C57BL/6 		no abnormal phenotype detected J:144991
Supv3l1tm2Jkl/Supv3l1tm2Jkl
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129P2/OlaHsd * C57BL/6 		abnormal dermal layer morphology J:144991
abnormal duodenum morphology J:144991
abnormal epidermis stratum granulosum morphology J:144991
abnormal locomotor behavior J:144991
abnormal lung interstitium morphology J:144991
abnormal skin morphology J:144991
abnormal T cell differentiation J:144991
acanthosis J:144991
cachexia J:144991
decreased body weight J:144991
decreased CD4-positive, alpha-beta T cell number J:144991
decreased CD8-positive, alpha-beta T cell number J:144991
decreased double-negative T cell number J:144991
decreased double-positive T cell number J:144991
decreased sebaceous gland number J:144991
decreased skeletal muscle mass J:144991
decreased subcutaneous adipose tissue amount J:144991
dilated vasculature J:144991
dystrophic muscle J:144991
hyperkeratosis J:144991
increased macrophage derived foam cell number J:144991
normal integument phenotype J:144991
kyphosis J:144991
lung inflammation J:144991
parakeratosis J:144991
premature death J:144991
reddish skin J:144991
scaly skin J:144991
thick epidermis J:144991
thymus atrophy J:144991
thymus hypoplasia J:144991
Supv3l1tm2Jkl/Supv3l1tm2Jkl
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal coat/ hair morphology J:144991
abnormal dermal layer morphology J:144991
abnormal ear morphology J:144991
abnormal epidermal layer morphology J:144991
abnormal locomotor behavior J:144991
abnormal lung interstitium morphology J:144991
acanthosis J:144991
alopecia J:144991
cachexia J:144991
decreased body weight J:144991
decreased hair follicle number J:144991
decreased sebaceous gland number J:144991
decreased total body fat amount J:144991
dilated vasculature J:144991
hypergranulosis J:144991
hyperkeratosis J:144991
increased macrophage derived foam cell number J:144991
increased plasma cell number J:144991
interstitial pneumonia J:144991
kyphosis J:144991
muscular atrophy J:144991
parakeratosis J:144991
postnatal growth retardation J:144991
premature death J:144991
scaly skin J:144991
thick epidermis J:144991
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
MGI 6.23 		The Jackson Laboratory