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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Dock1
dedicator of cytokinesis 1
MGI:2429765
31 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Dock1b2b3190Clo/Dock1b2b3190Clo
C57BL/6J-Dock1b2b3190Clo
atrioventricular septal defect J:175213
double outlet right ventricle J:175213
hydronephrosis J:175213
hydrops fetalis J:175213
micrognathia J:175213
persistent truncus arteriosis J:175213
pulmonary valve atresia J:175213
short snout J:175213
thymus hypoplasia J:175213
ventricular septal defect J:175213
Dock1tm1.1Ysfk/Dock1tm1.1Ysfk
B6(Cg)-Dock1tm1.1Ysfk
abnormal heart morphology J:178190
abnormal heart right ventricle outflow tract morphology J:178190
abnormal myogenesis J:178190
abnormal vascular endothelial cell migration J:178190
abnormal vasculogenesis J:178190
edema J:178190
lethality throughout fetal growth and development, incomplete penetrance J:178190
prenatal lethality, complete penetrance J:178190
thick mitral valve cusps J:178190
ventricular septal defect J:178190
Dock1tm1Jfco/Dock1tm1Jfco
involves: 129
abnormal heart right ventricle outflow tract morphology J:178190
abnormal myogenesis J:178190
edema J:178190
thick mitral valve cusps J:178190
ventricular septal defect J:178190
Dock1tm1Jfco/Dock1tm1Jfco
involves: 129/Sv * C57BL/6
abnormal diaphragm morphology J:143342
abnormal intercostal muscle morphology J:143342
abnormal muscle development J:143342
abnormal muscle physiology J:143342
atelectasis J:143342
cyanosis J:143342
decreased birth body size J:143342
decreased skeletal muscle fiber diameter J:143342
decreased skeletal muscle mass J:143342
lethality at weaning, complete penetrance J:143342
thin diaphragm muscle J:143342
Dock1tm2.1Jfco/Dock1tm2.1Jfco
Tg(MMTV-cre)7Mul/0
involves: C57BL/6 * FVB/N * FVB/NJ
normal endocrine/exocrine gland phenotype J:196659

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory