Irak2 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Irak2
interleukin-1 receptor-associated kinase 2
MGI:2429603

12 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Irak2^tm1.1Pcoh/? involves: C57BL/6	decreased interferon-alpha secretion	J:205798
Irak2^tm1Aki/Irak2^tm1Aki involves: 129/Sv * C57BL/6	abnormal macrophage physiology	J:136290
Irak2^tm1Aki/Irak2^tm1Aki involves: 129/Sv * C57BL/6	decreased susceptibility to endotoxin shock	J:136290
Irak2^{tm1b(EUCOMM)Wtsi}/Irak2^{tm1b(EUCOMM)Wtsi} C57BL/6N-Irak2^{tm1b(EUCOMM)Wtsi}/H	increased circulating alkaline phosphatase level	J:211773
	increased total body fat amount	J:211773
	short tibia	J:211773
Irak2^tm1Jth/Irak2^tm1Jth involves: 129 * C57BL/6	abnormal chemokine level	J:149258
	decreased circulating interleukin-6 level	J:149258
	decreased circulating tumor necrosis factor level	J:149258
	decreased interleukin-6 secretion	J:149258
	decreased susceptibility to endotoxin shock	J:149258
	decreased susceptibility to induced morbidity/mortality	J:149258
	decreased tumor necrosis factor secretion	J:149258

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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