Gabbr2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gabbr2
gamma-aminobutyric acid type B receptor subunit 2
MGI:2386030

27 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo involves: 129S2/SvPas * C57BL/6J	abnormal excitatory postsynaptic currents	J:205570
	abnormal hippocampus CA1 region morphology	J:205570
	abnormal hippocampus physiology	J:205570
	abnormal long-term spatial reference memory	J:205570
	abnormal synapse morphology	J:205570
	abnormal synaptic plasticity	J:205570
	impaired contextual conditioning behavior	J:205570
Gabbr2^tm1Arca/Gabbr2^tm1Arca involves: 129P2/OlaHsd	abnormal inhibitory postsynaptic currents	J:146953
	abnormal inhibitory postsynaptic potential	J:146953
	decreased body weight	J:146953
	premature death	J:146953
	seizures	J:146953
	tonic-clonic seizures	J:146953
Gabbr2^tm1Bet/Gabbr2⁺ BALB/c-Gabbr2^tm1Bet	abnormal emotion/affect behavior	J:103534
Gabbr2^tm1Bet/Gabbr2^tm1Bet BALB/c-Gabbr2^tm1Bet	abnormal brain wave pattern	J:103989
	abnormal depression-related behavior	J:103534
	abnormal emotion/affect behavior	J:103989
	abnormal excitatory postsynaptic currents	J:103989
	abnormal inhibitory postsynaptic currents	J:103989
	abnormal nervous system electrophysiology	J:103989
	abnormal synaptic transmission	J:103534
	abnormal touch/ nociception	J:103989
	clonic seizures	J:103989
	decreased physiological sensitivity to xenobiotic	J:103989
	decreased thermal nociceptive threshold	J:103989
	hyperresponsive to tactile stimuli	J:103989
	impaired behavioral response to xenobiotic	J:103989
	impaired passive avoidance behavior	J:103989
	increased anxiety-related response	J:103534
	increased locomotor activity	J:103989

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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