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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Cnot3
CCR4-NOT transcription complex, subunit 3
MGI:2385261
62 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Cnot3em1(IMPC)Rbrc/Cnot3+
C57BL/6NJcl-Cnot3em1(IMPC)Rbrc/Rbrc
abnormal behavior J:211773
abnormal kidney morphology J:211773
abnormal liver morphology J:211773
abnormal male genitalia morphology J:211773
abnormal uterus morphology J:211773
absent external male genitalia J:211773
decreased bone mineral content J:211773
decreased bone mineral density J:211773
decreased circulating triglyceride level J:211773
decreased locomotor activity J:211773
hydrometra J:211773
hyperactivity J:211773
improved glucose tolerance J:211773
increased circulating bilirubin level J:211773
increased thigmotaxis J:211773
Cnot3tm1.1Kjkb/Cnot3tm1.1Kjkb
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129P2/OlaHsd * C57BL/6 * FVB/N
congestive heart failure J:260012
premature death J:260012
Cnot3tm1.1Kjkb/Cnot3tm1.1Kjkb
Tg(Ckmm-cre)5Khn/0
involves: 129P2/OlaHsd * C57BL/6 * FVB
cardiac muscle necrosis J:260012
cardiomyopathy J:260012
decreased cardiac muscle contractility J:260012
decreased myocardial fiber number J:260012
enlarged heart J:260012
increased heart weight J:260012
irregular heartbeat J:260012
normal muscle phenotype J:260012
premature death J:260012
prolonged QT interval J:260012
Cnot3tm1.1Tya/Cnot3+
B6.129P2(Cg)-Cnot3tm1.1Tya
abnormal bone mineralization J:206802
abnormal osteoclast differentiation J:206802
abnormal skeleton development J:206802
abnormal trabecular bone morphology J:206802
decreased birth body size J:180033
decreased body fat mass J:180033
decreased body length J:180033
decreased body weight J:180033
decreased bone mineral density J:206802
decreased bone trabecula number J:206802
decreased brown fat cell size J:180033
decreased circulating glucose level J:180033
decreased circulating triglyceride level J:180033
decreased compact bone thickness J:206802
decreased fasting circulating glucose level J:180033
decreased percent body fat/body weight J:180033
decreased subcutaneous adipose tissue amount J:180033
decreased susceptibility to diet-induced hepatic steatosis J:180033
decreased susceptibility to diet-induced obesity J:180033
decreased trabecular bone mass J:206802
decreased trabecular bone thickness J:206802
decreased white fat cell size J:180033
improved glucose tolerance J:180033
increased bone resorption J:206802
increased insulin sensitivity J:180033
increased osteoclast cell number J:206802
increased oxygen consumption J:180033
osteoporosis J:206802
small liver J:180033
Cnot3tm1.1Tya/Cnot3tm1.1Tya
B6.129P2(Cg)-Cnot3tm1.1Tya
embryonic lethality, complete penetrance J:180033
Cnot3tm1Pngr/Cnot3+
B6.Cg-Cnot3tm1Pngr
abnormal cardiovascular system physiology J:167954
abnormal heart morphology J:167954
cardiac fibrosis J:167954
cardiac hypertrophy J:167954
decreased cardiac muscle contractility J:167954
decreased left ventricle developed pressure J:167954
decreased ventricle muscle contractility J:167954
increased heart left ventricle size J:167954
increased heart weight J:167954
Cnot3tm1Pngr/Cnot3tm1Pngr
B6.Cg-Cnot3tm1Pngr
abnormal inner cell mass morphology J:167954
embryonic lethality at implantation, complete penetrance J:167954

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory