Smc5 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Smc5
structural maintenance of chromosomes 5
MGI:2385088

21 phenotypes from 3 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/0 Smc5^{tm1c(KOMP)Wtsi}/Smc5^{tm1d(KOMP)Wtsi} involves: 129S4/SvJae * C57BL/6N * CBA	abnormal cell cycle	J:240155
	abnormal cell differentiation	J:240155
	abnormal mitosis	J:240155
	abnormal mitotic spindle assembly checkpoint	J:240155
	abnormal mitotic spindle morphology	J:240155
	normal cellular phenotype	J:240155
	increased cell death	J:240155
	increased mitotic index	J:240155
	mitotic nondisjunction	J:240155
Smc5^{tm1b(KOMP)Wtsi}/Smc5⁺ C57BL/6N-Smc5^{tm1b(KOMP)Wtsi}/Ics	decreased circulating cholesterol level	J:211773
	decreased circulating glucose level	J:211773
	decreased circulating HDL cholesterol level	J:211773
	decreased erythrocyte cell number	J:211773
	decreased hematocrit	J:211773
	decreased lymphocyte cell number	J:211773
	increased circulating bilirubin level	J:211773
	increased eosinophil cell number	J:211773
	increased neutrophil cell number	J:211773
	thrombocytopenia	J:211773
	tremors	J:211773
Smc5^{tm1b(KOMP)Wtsi}/Smc5^{tm1b(KOMP)Wtsi} C57BL/6N-Smc5^{tm1b(KOMP)Wtsi}/Ics	preweaning lethality, complete penetrance	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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