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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Irak4
interleukin-1 receptor-associated kinase 4
MGI:2182474
20 phenotypes from 5 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Irak4m1Btlr/Irak4m1Btlr
C57BL/6J-Irak4m1Btlr 		decreased tumor necrosis factor secretion J:133271
Irak4tm1Aki/Irak4tm1Aki
involves: 129X1/SvJ * C57BL/6 		abnormal cytokine secretion J:125729
decreased B cell proliferation J:125729
decreased interferon-alpha secretion J:125729
decreased interleukin-6 secretion J:125729
decreased interleukin-12b secretion J:125729
decreased susceptibility to endotoxin shock J:125729
decreased tumor necrosis factor secretion J:125729
normal immune system phenotype J:125729
Irak4tm1Gram/Irak4tm1Gram
involves: BALB/c 		abnormal chemokine secretion J:121912
abnormal cytokine secretion J:121912
abnormal fibroblast physiology J:121912
Irak4tm1Lix/Irak4tm1Lix
involves: C57BL/6 		abnormal chemokine secretion J:125732
decreased acute inflammation J:125732
decreased circulating interleukin-6 level J:125732
decreased circulating tumor necrosis factor level J:125732
decreased interferon-alpha secretion J:125732
decreased interferon-beta secretion J:125732
decreased interleukin-6 secretion J:125732
decreased susceptibility to endotoxin shock J:125732
decreased tumor necrosis factor secretion J:125732
Irak4tm1Yeh/Irak4tm1Yeh
involves: 129P2/OlaHsd * C57BL/6J 		abnormal cytokine level J:76098
abnormal cytokine secretion J:76098
abnormal macrophage physiology J:76098
abnormal NK cell physiology J:76098
decreased B cell proliferation J:76098
decreased circulating interferon-gamma level J:76098
decreased circulating interleukin-1 level J:76098
decreased circulating interleukin-6 level J:76098
decreased circulating tumor necrosis factor level J:76098
decreased interleukin-6 secretion J:76098
decreased susceptibility to endotoxin shock J:76098
decreased tumor necrosis factor secretion J:76098
increased susceptibility to bacterial infection J:76098
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory