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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Dicer1
dicer 1, ribonuclease type III
MGI:2177178
254 phenotypes from 22 alleles in 37 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Aicdatm1(cre)Njen/Aicda+
Dicer1tm1Bdh/Dicer1tm1Bdh
involves: 129 * C57BL/6
abnormal germinal center B cell physiology J:181782
abnormal humoral immune response J:181782
absent memory B cells J:181782
absent plasma cells J:181782
decreased germinal center B cell number J:181782
decreased immunoglobulin level J:181782
normal immune system phenotype J:181782
Alpltm1(cre)Nagy/Alpl+
Dicer1tm1.1Mnn/Dicer1tm1.2Mnn
involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J
abnormal meiotic spindle morphology J:150221
abnormal oocyte morphology J:150221
Amhr2tm3(cre)Bhr/Amhr2+
Dicer1tm1Bdh/Dicer1tm1Bdh
involves: 129
abnormal oviduct morphology J:142113
abnormal oviduct transport J:142113
abnormal pregnancy J:142113
abnormal superovulation J:142113
abnormal uterus morphology J:142113
decreased circulating progesterone level J:142113
decreased endometrial gland number J:142113
decreased ovary weight J:142113
decreased ovulation rate J:142113
decreased uterus weight J:142113
failure of embryo implantation J:142113
female infertility J:142113
normal homeostasis/metabolism phenotype J:142113
normal reproductive system phenotype J:142113
short oviduct J:142113
short uterine horn J:142113
small uterus J:142113
thin myometrium J:142113
Defb41tm1(icre)Psip/Defb41+
Dicer1tm1Bdh/Dicer1tm1Bdh
involves: 129S6/SvEvTac * C57BL/6N
abnormal efferent ductules of testis morphology J:187838
abnormal epididymis epithelium morphology J:187838
abnormal epididymis morphology J:187838
abnormal seminiferous tubule epithelium morphology J:187838
dilated efferent ductules of testis J:187838
increased epididymal epithelium cell proliferation J:187838
male infertility J:187838
oligozoospermia J:187838
small epididymis J:187838
Dicer1em1Psv/Dicer1em1Psv
involves: C57BL/6NCrl
abnormal female meiosis J:203415
abnormal meiotic spindle morphology J:203415
female infertility J:203415
normal reproductive system phenotype J:203415
Dicer1em2Psv/Dicer1em2Psv
involves: C57BL/6NCrl
abnormal female meiosis J:203415
abnormal meiotic spindle morphology J:203415
female infertility J:203415
normal reproductive system phenotype J:203415
Dicer1em3Psv/Dicer1em3Psv
involves: C57BL/6NCrl
abnormal female meiosis J:203415
abnormal meiotic spindle morphology J:203415
female infertility J:203415
normal reproductive system phenotype J:203415
Dicer1Gt(RRF266)Byg/Dicer1Gt(RRF266)Byg
involves: 129P2/OlaHsd * C57BL/6
abnormal angiogenesis J:123635
decreased susceptibility to viral infection J:123635
embryonic lethality during organogenesis, incomplete penetrance J:108137
increased susceptibility to viral infection J:123635
perinatal lethality, incomplete penetrance J:108137, J:123635
Dicer1m1Btlr/Dicer1m1Btlr
C57BL/6J-Dicer1m1Btlr
decreased CD4-positive, alpha beta T cell number J:265172
decreased CD8-positive, alpha-beta T cell number J:265172
decreased CD8-positive, naive alpha-beta T cell number J:265172
decreased single-positive T cell number J:265172
decreased T cell number J:265172
increased B-1 B cell number J:265172
increased central memory CD8 positive, alpha-beta T cell number J:265172
increased effector memory CD4-positive, alpha-beta T cell number J:265172
increased effector memory CD8-positive, alpha-beta T cell number J:265172
Dicer1tm1.1Bdh/Dicer1tm1.1Bdh
involves: 129
embryonic growth arrest J:100475
embryonic lethality between implantation and somite formation, complete penetrance J:100475
Dicer1tm1.1Doca/Dicer1tm1.1Doca
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
no abnormal phenotype detected J:228491
Dicer1tm1.1Mnn/Dicer1tm1.2Mnn
Tg(Zp3-cre)93Knw/0
involves: 129S1/SvImJ * C57BL/6J
abnormal female meiosis J:150221
abnormal meiotic spindle morphology J:150221
abnormal oocyte morphology J:150221
female infertility J:150221
Dicer1tm1.1Snj/Dicer1tm1.1Snj
involves: 129S7/SvEvBrd * C57BL/6
decreased embryo size J:139257
Dicer1tm1.1Vlcg/Dicer1tm1.1Vlcg
involves: 129S6/SvEvTac * C57BL/6NTac
abnormal embryo development J:200671
Dicer1tm1.1Vlcg/Dicer1tm2.1Vlcg
Tg(Nanog-cre)#Vlcg/0
involves: 129S6/SvEvTac * C57BL/6NTac
abnormal embryo development J:200671
embryonic lethality, complete penetrance J:200671
Dicer1tm1b(EUCOMM)Wtsi/Dicer1+
C57BL/6N-Dicer1tm1b(EUCOMM)Wtsi/H
decreased neutrophil cell number J:211773
decreased red blood cell distribution width J:211773
decreased spleen weight J:211773
Dicer1tm1b(EUCOMM)Wtsi/Dicer1tm1b(EUCOMM)Wtsi
C57BL/6N-Dicer1tm1b(EUCOMM)Wtsi/H
embryonic lethality prior to organogenesis J:211773
preweaning lethality, complete penetrance J:211773
Dicer1tm1Bdh/Dicer1+
H2az2Tg(Wnt1-cre)11Rth/0
involves: 129 * C57BL/6 * CBA/J
abnormal thymus development J:166758
Dicer1tm1Bdh/Dicer1tm1Bdh
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129 * C57BL/6 * CBA
spina bifida J:244791
Dicer1tm1Bdh/Dicer1tm1Bdh
Foxp3tm4(YFP/icre)Ayr/Y
involves: 129S1/Sv * 129X1/SvJ
enlarged lymph nodes J:138683
enlarged spleen J:138683
liver inflammation J:138683
lung inflammation J:138683
premature death J:138683
vascular inflammation J:138683
Dicer1tm1Bdh/Dicer1tm1Bdh
Foxp3tm4(YFP/icre)Ayr/Foxp3tm4(YFP/icre)Ayr
involves: 129S1/Sv * 129X1/SvJ
enlarged lymph nodes J:138683
enlarged spleen J:138683
liver inflammation J:138683
lung inflammation J:138683
premature death J:138683
vascular inflammation J:138683
Dicer1tm1Bdh/Dicer1tm1Bdh
H2az2Tg(Wnt1-cre)11Rth/0
involves: 129 * C57BL/6 * CBA/J
abnormal aortic arch development J:166758
abnormal cartilage morphology J:166758
abnormal craniofacial morphology J:166758
abnormal dorsal root ganglion morphology J:166758
abnormal first pharyngeal arch morphology J:166758
abnormal sympathetic ganglion morphology J:166758
athymia J:166758
lethality throughout fetal growth and development, complete penetrance J:166758
persistent truncus arteriosis J:166758
ventricular septal defect J:166758
Dicer1tm1Bdh/Dicer1tm1Bdh
Hprttm1(Pck1-cre)Vhh/Y
involves: 129 * 129P2/OlaHsd
decreased susceptibility to kidney reperfusion injury J:185838
normal renal/urinary system phenotype J:185838
Dicer1tm1Bdh/Dicer1tm1Bdh
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129 * 129S7/SvEvBrd * C57BL/6
abnormal cardiovascular system physiology J:211548
abnormal myocardium layer morphology J:211548
embryonic lethality during organogenesis, complete penetrance J:211548
pericardial edema J:211548
Dicer1tm1Bdh/Dicer1tm1Bdh
Plekha5Tg(AMH-cre)1Flor/0
involves: 129/Sv * C57BL/6 * SJL
abnormal male germ cell apoptosis J:145178
abnormal male germ cell morphology J:145178
abnormal seminiferous tubule epithelium morphology J:145178
abnormal Sertoli cell morphology J:145178
abnormal spermatid morphology J:145178
abnormal spermatogenesis J:145178
azoospermia J:145178
decreased male germ cell number J:145178
decreased testis weight J:145178
ectopic Sertoli cells J:145178
Leydig cell hyperplasia J:145178
male infertility J:145178
normal reproductive system phenotype J:145178
seminiferous tubule degeneration J:145178
small seminiferous tubules J:145178
small testis J:145178
testis degeneration J:145178
Dicer1tm1Bdh/Dicer1tm1Bdh
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129
abnormal lung development J:106072
abnormal lung epithelium morphology J:106072
perinatal lethality, complete penetrance J:106072
small lung lobe J:106072
Dicer1tm1Bdh/Dicer1tm1Bdh
Sox1tm1(cre)Take/Sox1+
involves: 129 * C57BL/6NCrlj * CBA/JNCrlj
perinatal lethality, complete penetrance J:244791
short rostral-caudal axis J:244791
Dicer1tm1Bdh/Dicer1tm1Bdh
Tg(Cd4-cre)1Cwi/0
involves: 129 * C57BL/6 * DBA/2
decreased regulatory T cell number J:138683
Dicer1tm1Bdh/Dicer1tm1Bdh
Tg(Foxp3-EGFP/icre)1aJbs/0
involves: 129 * NOD/ShiLt
abnormal behavior J:138808
abnormal CD4-positive, alpha-beta T cell physiology J:138808
abnormal effector T cell morphology J:138808
abnormal lymph node cell ratio J:138808
abnormal regulatory T cell morphology J:138808
abnormal regulatory T cell physiology J:138808
abnormal splenic cell ratio J:138808
decreased regulatory T cell number J:138808
enlarged lymph nodes J:138808
enlarged spleen J:138808
kyphosis J:138808
liver inflammation J:138808
lung inflammation J:138808
premature death J:138808
weight loss J:138808
Dicer1tm1Bdh/Dicer1tm1Bdh
Tg(Prrx1-cre)1Cjt/0
involves: 129 * C57BL/6J * SJL/J
abnormal forelimb morphology J:100475
abnormal hindlimb morphology J:100475
abnormal long bone morphology J:100475
delayed endochondral bone ossification J:100475
oligodactyly J:100475
Dicer1tm1Dli/Dicer1tm1Dli
Tg(Cd4-cre)1Cwi/?
involves: 129 * C57BL/6 * DBA/2
abnormal cell physiology J:100546
abnormal cytotoxic T cell physiology J:100546
abnormal T-helper 1 physiology J:100546
abnormal T-helper 2 physiology J:100546
decreased T cell number J:100546
decreased T cell proliferation J:100546
normal immune system phenotype J:100546
increased T cell apoptosis J:100546
Dicer1tm1Ghan/Dicer1tm1Ghan
involves: 129S7/SvEvBrd
decreased embryo size J:86391
embryonic growth arrest J:86391
embryonic lethality between implantation and somite formation, complete penetrance J:86391
Dicer1tm1Gz/Dicer1tm1Gz
involves: 129P2/OlaHsd * C57BL/6
abnormal angiogenesis J:97770
abnormal blood vessel morphology J:97770
abnormal vitelline vascular remodeling J:97770
absent vitelline blood vessels J:97770
decreased embryo size J:97770
lethality throughout fetal growth and development, complete penetrance J:97770
small liver J:97770
Dicer1tm1Mmk/Dicer1tm1.1Mmk
Cd79atm1(cre)Reth/Cd79a+
involves: BALB/c
abnormal immunoglobulin V(D)J recombination J:135783
decreased B cell number J:135783
Dicer1tm1Mmk/Dicer1tm1Mmk
Cd79atm1(cre)Reth/Cd79a+
involves: BALB/c
arrested B cell differentiation J:135783
decreased immature B cell number J:135783
decreased mature B cell number J:135783
decreased pre-B cell number J:135783
increased pro-B cell number J:135783
Dicer1tm1Mmk/Dicer1tm1Mmk
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129 * C57BL/6J
abnormal branching involved in lung morphogenesis J:224791
abnormal lung epithelium morphology J:224791
abnormal lung-associated mesenchyme development J:224791
enlarged lung J:224791
increased mesenchymal cell proliferation involved in lung development J:224791
lung cysts J:224791
Dicer1tm1Mmk/Dicer1tm1Mmk
Tg(BGLAP-cre)1Clem/0
involves: 129 * C57BL/6 * FVB/N
abnormal bone structure J:158901
normal hematopoietic system phenotype J:158901
increased compact bone volume J:158901
Dicer1tm1Mmk/Dicer1tm1Mmk
Tg(Lck-cre)1Cwi/0
involves: C57BL/6 * DBA/2
decreased T cell number J:98192
decreased thymocyte number J:98192
increased gamma-delta T cell number J:98192
Dicer1tm1Mmk/Dicer1tm1Mmk
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
involves: 129 * C57BL/6 * CD-1
abnormal bone marrow morphology J:158901
abnormal bone structure J:158901
abnormal cardiovascular system morphology J:158901
abnormal granulocyte differentiation J:158901
abnormal megakaryocyte differentiation J:158901
abnormal megakaryocyte morphology J:158901
abnormal myeloid leukocyte morphology J:158901
abnormal neutrophil morphology J:158901
abnormal skeleton development J:158901
anemia J:158901
decreased B cell number J:158901
decreased leukocyte cell number J:158901
decreased osteoblast cell number J:158901
enlarged spleen J:158901
extramedullary hematopoiesis J:158901
giant platelets J:158901
normal hematopoietic system phenotype J:158901
impaired hematopoiesis J:158901
increased bone marrow cell number J:158901
increased facial tumor incidence J:158901
increased hemolymphoid system tumor incidence J:158901
increased leukemia incidence J:158901
increased myeloid sarcoma incidence J:158901
postnatal growth retardation J:158901
premature death J:158901
thrombocytopenia J:158901
Dicer1tm1Smr/Dicer1tm1Smr
Pax8tm1.1(cre)Mbu/Pax8+
involves: 129P2/OlaHsd * 129S7/SvEvBrd
abnormal kidney morphology J:229188
abnormal renal corpuscle morphology J:229188
abnormal renal glomerulus morphology J:229188
abnormal renal tubule epithelial cell primary cilium morphology J:229188
albuminuria J:229188
decreased body weight J:229188
decreased kidney collecting duct number J:229188
decreased kidney weight J:229188
decreased renal glomerular filtration rate J:229188
decreased urine osmolality J:229188
dilated renal glomerular capsule J:229188
dilated renal tubules J:229188
increased fluid intake J:229188
increased kidney apoptosis J:229188
increased kidney cell proliferation J:229188
increased urine protein level J:229188
isosthenuria J:229188
kidney cortex cysts J:229188
pale kidney J:229188
polyuria J:229188
renal interstitial fibrosis J:229188
Dicer1tm1Smr/Dicer1tm1Smr
Tg(KRT5-rtTA)1Glk/0
Tg(tetO-cre)1Jaw/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
abnormal coat/ hair morphology J:183487
abnormal hair cycle catagen phase J:183487
abnormal hair follicle bulge morphology J:183487
abnormal hair follicle inner root sheath morphology J:183487
abnormal hair follicle morphology J:183487
abnormal hair follicle regression J:183487
abnormal hair growth J:183487
abnormal hair shaft morphology J:183487
abnormal skin physiology J:183487
alopecia J:183487
decreased body size J:183487
dry skin J:183487
epidermal hyperplasia J:183487
hair follicle degeneration J:183487
increased apoptosis J:183487
normal integument phenotype J:183487
scaly skin J:183487
small hair follicles J:183487
waved hair J:183487
Dicer1tm1Smr/Dicer1tm1Smr
Tg(KRT14-cre)52Smr/0
involves: 129S7/SvEvBrd * C57BL/6J * SJL/J
abnormal epidermal layer morphology J:110268
abnormal hair follicle development J:110268
abnormal hair follicle orientation J:110268
abnormal hair shaft morphology J:110268
decreased hair follicle cell proliferation J:110268
delayed hair appearance J:110268
hair follicle degeneration J:110268
postnatal growth retardation J:110268
postnatal lethality, incomplete penetrance J:110268
premature death J:110268
small hair follicle bulb J:110268
thick epidermis J:110268
Dicer1tm1Smr/Dicer1tm1Smr
Tg(Myh6-cre)2182Mds/0
involves: 129S7/SvEvBrd * FVB/N
abnormal atrial thrombosis J:131962
abnormal cardiac thrombosis J:131962
abnormal fetal cardiomyocyte morphology J:131962
abnormal heart echocardiography feature J:131962
abnormal myocardial fiber morphology J:131962
abnormal sarcomere morphology J:131962
congestive heart failure J:131962
decreased cardiac muscle contractility J:131962
decreased heart rate J:131962
dilated cardiomyopathy J:131962
dilated heart left ventricle J:131962
disorganized myocardium J:131962
enlarged heart J:131962
hypoactivity J:131962
increased cardiomyocyte apoptosis J:131962
postnatal lethality, complete penetrance J:131962
Dicer1tm1Snj/Dicer1tm1Snj
involves: 129S7/SvEvBrd * C57BL/6
no abnormal phenotype detected J:139257
Dicer1tm1Snj/Dicer1tm1Snj
involves: 129S7/SvEvBrd * C57BL/6
abnormal cell physiology J:139257
abnormal DNA replication J:139257
abnormal mitosis J:139257
decreased cell proliferation J:139257
early cellular replicative senescence J:139257
Dicer1tm1Snj/Dicer1tm1Snj
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129S7/SvEvBrd * C57BL/6 * CBA
abnormal limb development J:139257
Dicer1tm1Snj/Dicer1tm1Snj
Tg(KRT5-cre/PGR)1Der/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR
abnormal epidermal layer morphology J:139257, J:216813
abnormal hair follicle morphology J:216813
abnormal skin physiology J:216813
alopecia J:139257
cachexia J:216813
decreased hair follicle number J:216813
hair follicle degeneration J:216813
loss of vibrissae J:216813
normal neoplasm J:216813
premature death J:216813
progressive hair loss J:216813
thick epidermis J:216813
Dicer1tm1Tara/Dicer1tm1Tara
Amhr2tm3(cre)Bhr/Amhr2+
involves: 129P2/OlaHsd * 129S7/SvEvBrd
normal neoplasm J:222579
Dicer1tm1Tara/Dicer1tm1Tara
Foxn1tm3(cre)Nrm/Foxn1+
involves: 129P2/OlaHsd * C57BL/6NHsd
abnormal positive T cell selection J:180783
abnormal thymus cortex morphology J:180783
abnormal thymus epithelium morphology J:180783
abnormal thymus involution J:180783
abnormal thymus medulla morphology J:180783
abnormal thymus morphology J:180783
abnormal thymus physiology J:180783
decreased CD4-positive, alpha beta T cell number J:180783
decreased CD8-positive, alpha-beta T cell number J:180783
increased susceptibility to induced arthritis J:180783
Dicer1tm1Tara/Dicer1tm1Tara
Tg(KRT14-cre)1Efu/0
involves: 129P2/OlaHsd
abnormal coat/ hair morphology J:201587
abnormal hair follicle development J:183622, J:201587
abnormal hair follicle morphology J:183622
abnormal skin appearance J:201587
abnormal skin physiology J:183622
decreased body size J:201587
epidermal cyst J:183622
Dicer1tm1Tara/Dicer1tm1Tara
Tg(KRT14-cre)1Efu/?
involves: 129P2/OlaHsd * CD-1
abnormal hair follicle morphology J:106792
abnormal vibrissa morphology J:106792
dehydration J:106792
increased apoptosis J:106792
postnatal lethality, complete penetrance J:106792
Dicer1tm2.1Vlcg/Dicer1tm2.1Vlcg
involves: 129S6/SvEvTac * C57BL/6NTac
no abnormal phenotype detected J:200671

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last database update
09/17/2019
MGI 6.14
The Jackson Laboratory