Mlc1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mlc1
megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)
MGI:2157910

19 phenotypes from 5 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Mlc1^{tm1.1(KOMP)Vlcg}/Mlc1^{tm1.1(KOMP)Vlcg} C57BL/6N-Mlc1^{tm1.1(KOMP)Vlcg}/Ucd	abnormal uterus morphology	J:211773
	increased brain weight	J:211773
Mlc1^tm1.1Rhn/Mlc1^tm1.1Rhn Tg(Mlc1-tTA)2Rhn/0 129S6.Cg-Mlc1^tm1.1Rhn Tg(Mlc1-tTA)2Rhn	abnormal astrocyte morphology	J:237219
	abnormal brain white matter morphology	J:237219
	abnormal corpus callosum morphology	J:237219
	abnormal myelin sheath morphology	J:237219
	astrocytosis	J:237219
	ataxia	J:237219
	brain vacuoles	J:237219
	normal reproductive system phenotype	J:237219
	slow postnatal weight gain	J:237219
Mlc1^tm1.1Vdk/Mlc1^tm1.1Vdk involves: C57BL/6	abnormal astrocyte morphology	J:244698, J:250520
	abnormal astrocyte physiology	J:250520
	abnormal myelin sheath morphology	J:250520
	normal behavior/neurological phenotype	J:250520
	brain vacuoles	J:244698, J:250520
	cerebral edema	J:250520
	increased brain size	J:250520
	increased brain weight	J:250520
Mlc1^tm1.2Nune/Mlc1^tm1.2Nune involves: 129 * C57BL/6	abnormal glial cell physiology	J:210308
	abnormal myelin sheath morphology	J:210308
	abnormal oligodendrocyte physiology	J:210308
	brain vacuoles	J:210308
Mlc1^tm1Rhn/Mlc1^tm1Rhn 129S6/SvEvTac-Mlc1^tm1Rhn	abnormal astrocyte morphology	J:237219
	abnormal brain white matter morphology	J:237219
	abnormal cerebellum morphology	J:237219
	abnormal myelin sheath morphology	J:237219
	normal behavior/neurological phenotype	J:237219
	brain vacuoles	J:237219
	edema	J:237219

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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